An historical approach to the genetic distribution of KIR and HLA ligands in Eastern Sicilians compared to modern descendants of their invaders

Cristina Capittini, Francesco Messina, Fabrizio Puglisi, Maria Azzaro, Sebastiana Toscano, Annalisa De Silvestri, Carmine Tinelli, Grazia Sortino

Research output: Contribution to journalArticlepeer-review

Abstract

A geographical stratification of Killer Immunoglobulin-like Receptors (KIR) has been reported worldwide. We first analyzed the distribution of 15 KIR genes in a sample of 50 East-Sicilians (ES). We used a Principal Component Analysis (PCA) to compare the KIR genetic content among ES and 10 modern populations who are descendants of the ancient invaders of Sicily: Spanish, French, Norwegians, Swedes, Finns, Tunisians, Moroccans, Arabs, Greeks, Turks. We also included a sample of Sardinians, and Senegalese (as outlier group). Then, we also compared the HLA-A, HLA-B and HLA-C allelic frequencies among ES and the same populations investigated for KIR. As to HLA-A and HLA-B polymorphisms, ES are close to Greek population who invaded the island for long time until 827 CE; while HLA-C and KIR distribution in ES are close to Spanish population that invaded Sicily (and Sardinia) starting from 1283. As to KIR, ES are close to Spanish and Sardinians. The immunogenetic fingerprint of ES may be the finely balanced result of the invasions that overwhelmed Sicily over the centuries.

Original languageEnglish
Pages (from-to)5-12
Number of pages8
JournalHuman Immunology
Volume79
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

Keywords

  • Human Leukocyte Antigens
  • Immune system
  • Killer Immunoglobulin-like Receptors
  • Population genetics
  • Sicily

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'An historical approach to the genetic distribution of KIR and HLA ligands in Eastern Sicilians compared to modern descendants of their invaders'. Together they form a unique fingerprint.

Cite this