TY - JOUR
T1 - An HIV type 2 case series in Italy
T2 - A phylogenetic analysis
AU - D'ettorre, Gabriella
AU - Lo Presti, Alessandra
AU - Gori, Caterina
AU - Cella, Eleonora
AU - Bertoli, Ada
AU - Vullo, Vincenzo
AU - Perno, Carlo Federico
AU - Ciotti, Marco
AU - Foley, Brian T.
AU - Ciccozzi, Massimo
PY - 2013/9/1
Y1 - 2013/9/1
N2 - In recent years, the increase of migration from countries where human immunodeficiency virus type 2 (HIV-2) is endemic to industrialized countries has facilitated the spread of the virus in individuals previously unexposed to this threat. In this report, we performed a phylogenetic analysis on pol and env sequences of HIV-2 strains identified in foreigners and native citizens to trace the origin of infection. All but one of the 17 pol gene sequences were classified as group A. HIV-2 strains were aggregated in several clusters depending by the country of origin and/or infection. One patient (1AA) was classified as being infected with a recombinant between HIV-2 group A and HIV-2 group B, because the pol gene sequence was clearly in the group A, but an env V3 region sequence from this patient was more similar to group B viruses. Therefore, it is urgent to strengthen the surveillance and use adequate molecular virological tools to diagnose and monitor HIV-2 infection.
AB - In recent years, the increase of migration from countries where human immunodeficiency virus type 2 (HIV-2) is endemic to industrialized countries has facilitated the spread of the virus in individuals previously unexposed to this threat. In this report, we performed a phylogenetic analysis on pol and env sequences of HIV-2 strains identified in foreigners and native citizens to trace the origin of infection. All but one of the 17 pol gene sequences were classified as group A. HIV-2 strains were aggregated in several clusters depending by the country of origin and/or infection. One patient (1AA) was classified as being infected with a recombinant between HIV-2 group A and HIV-2 group B, because the pol gene sequence was clearly in the group A, but an env V3 region sequence from this patient was more similar to group B viruses. Therefore, it is urgent to strengthen the surveillance and use adequate molecular virological tools to diagnose and monitor HIV-2 infection.
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U2 - 10.1089/aid.2013.0091
DO - 10.1089/aid.2013.0091
M3 - Article
C2 - 23638670
AN - SCOPUS:84883018192
VL - 29
SP - 1254
EP - 1259
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
SN - 0889-2229
IS - 9
ER -