An IgM monoclonal protein with multiple serological specificities

G. Merlini, A. Forsgren, I. Turesson, O. Zettervall

Research output: Contribution to journalArticlepeer-review


An IgM lambda M-component with a false Wasserman reaction and 'false' rheumatoid factor activity from a patient suffering from a well-differentiated lymphocytic lymphoma is presented. The monoclonal protein showed antibody activity against cardiolipin and cross-reacted with acryl particles, not with human IgG. Both these activities were found in the Fab fragment. The reduction of the 19S IgM to 7S IgM subunits was responsible for a strong decrease in activity. The importance of the IgM quaternary structure in determining antibody affinity is emphasized.

Original languageEnglish
Pages (from-to)276-282
Number of pages7
JournalClinical and Experimental Immunology
Issue number2
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Immunology


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