An IgM monoclonal protein with multiple serological specificities

G. Merlini, A. Forsgren, I. Turesson, O. Zettervall

Research output: Contribution to journalArticle


An IgM lambda M-component with a false Wasserman reaction and 'false' rheumatoid factor activity from a patient suffering from a well-differentiated lymphocytic lymphoma is presented. The monoclonal protein showed antibody activity against cardiolipin and cross-reacted with acryl particles, not with human IgG. Both these activities were found in the Fab fragment. The reduction of the 19S IgM to 7S IgM subunits was responsible for a strong decrease in activity. The importance of the IgM quaternary structure in determining antibody affinity is emphasized.

Original languageEnglish
Pages (from-to)276-282
Number of pages7
JournalClinical and Experimental Immunology
Issue number2
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of 'An IgM monoclonal protein with multiple serological specificities'. Together they form a unique fingerprint.

  • Cite this

    Merlini, G., Forsgren, A., Turesson, I., & Zettervall, O. (1979). An IgM monoclonal protein with multiple serological specificities. Clinical and Experimental Immunology, 37(2), 276-282.