An imbalanced OPG/TRAIL ratio is associated to severe acute myocardial infarction

Paola Secchiero, Federica Corallini, Antonio Paolo Beltrami, Claudio Ceconi, Vincenzo Bonasia, Antonio Di Chiara, Roberto Ferrari, Giorgio Zauli

Research output: Contribution to journalArticle

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Abstract

Background: This study was designed to evaluate the biological significance of simultaneous changes in the circulating levels of osteoprotegerin (OPG) and TNF-related apoptosis inducing ligand (TRAIL) in patients with coronary artery disease (CAD), and, in particular, with acute myocardial infarction (AMI). Methods: Total levels of OPG and TRAIL were measured by ELISA in patients with AMI (n=113), unstable angina (UA, n=21) and healthy controls (n=120). Results: Since OPG was elevated during the acute phase (first 12-24-48. h) after AMI and in patients with UA with respect to healthy controls, while TRAIL was decreased in acute AMI patients, CAD patients were characterized by an increased OPG/TRAIL ratio. Moreover, the OPG/TRAIL ratio was significantly (p

Original languageEnglish
Pages (from-to)274-277
Number of pages4
JournalAtherosclerosis
Volume210
Issue number1
DOIs
Publication statusPublished - May 2010

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TNF-Related Apoptosis-Inducing Ligand
Osteoprotegerin
Myocardial Infarction
Coronary Artery Disease
Unstable Angina
Enzyme-Linked Immunosorbent Assay

Keywords

  • Acute myocardial infarction
  • Heart failure
  • OPG
  • TRAIL

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Secchiero, P., Corallini, F., Beltrami, A. P., Ceconi, C., Bonasia, V., Di Chiara, A., ... Zauli, G. (2010). An imbalanced OPG/TRAIL ratio is associated to severe acute myocardial infarction. Atherosclerosis, 210(1), 274-277. https://doi.org/10.1016/j.atherosclerosis.2009.11.005

An imbalanced OPG/TRAIL ratio is associated to severe acute myocardial infarction. / Secchiero, Paola; Corallini, Federica; Beltrami, Antonio Paolo; Ceconi, Claudio; Bonasia, Vincenzo; Di Chiara, Antonio; Ferrari, Roberto; Zauli, Giorgio.

In: Atherosclerosis, Vol. 210, No. 1, 05.2010, p. 274-277.

Research output: Contribution to journalArticle

Secchiero, P, Corallini, F, Beltrami, AP, Ceconi, C, Bonasia, V, Di Chiara, A, Ferrari, R & Zauli, G 2010, 'An imbalanced OPG/TRAIL ratio is associated to severe acute myocardial infarction', Atherosclerosis, vol. 210, no. 1, pp. 274-277. https://doi.org/10.1016/j.atherosclerosis.2009.11.005
Secchiero P, Corallini F, Beltrami AP, Ceconi C, Bonasia V, Di Chiara A et al. An imbalanced OPG/TRAIL ratio is associated to severe acute myocardial infarction. Atherosclerosis. 2010 May;210(1):274-277. https://doi.org/10.1016/j.atherosclerosis.2009.11.005
Secchiero, Paola ; Corallini, Federica ; Beltrami, Antonio Paolo ; Ceconi, Claudio ; Bonasia, Vincenzo ; Di Chiara, Antonio ; Ferrari, Roberto ; Zauli, Giorgio. / An imbalanced OPG/TRAIL ratio is associated to severe acute myocardial infarction. In: Atherosclerosis. 2010 ; Vol. 210, No. 1. pp. 274-277.
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AU - Ferrari, Roberto

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