An immune-molecular hypothesis supporting infectious aetiopathogenesis of Kawasaki disease in children

Research output: Contribution to journalArticle

Abstract

The competitive binding between CpG-ODN (single-stranded DNA from pathogens) and HLA-B and HLA-A ligands for the inhibitory Killer Immunoglobulin-like Receptors (KIR)3DL1/2 may lead to possible hypo-sensing of pathogens and ineffective clearance. We observed an overabundance of HLA ligands for inhibitory KIR with three domains in KD subjects.

Original languageEnglish
Pages (from-to)543-545
Number of pages3
JournalEuropean Journal of Immunology
Volume48
Issue number3
DOIs
Publication statusPublished - Mar 2018

Fingerprint

KIR Receptors
Mucocutaneous Lymph Node Syndrome
Ligands
Competitive Binding
HLA-A Antigens
HLA-B Antigens
Single-Stranded DNA

Keywords

  • Child
  • Communicable Diseases/complications
  • HLA Antigens/genetics
  • Humans
  • Immunogenetic Phenomena
  • Ligands
  • Models, Immunological
  • Mucocutaneous Lymph Node Syndrome/etiology
  • Oligodeoxyribonucleotides/immunology
  • Receptors, KIR3DL1/metabolism
  • Receptors, KIR3DL2/metabolism

Cite this

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title = "An immune-molecular hypothesis supporting infectious aetiopathogenesis of Kawasaki disease in children",
abstract = "The competitive binding between CpG-ODN (single-stranded DNA from pathogens) and HLA-B and HLA-A ligands for the inhibitory Killer Immunoglobulin-like Receptors (KIR)3DL1/2 may lead to possible hypo-sensing of pathogens and ineffective clearance. We observed an overabundance of HLA ligands for inhibitory KIR with three domains in KD subjects.",
keywords = "Child, Communicable Diseases/complications, HLA Antigens/genetics, Humans, Immunogenetic Phenomena, Ligands, Models, Immunological, Mucocutaneous Lymph Node Syndrome/etiology, Oligodeoxyribonucleotides/immunology, Receptors, KIR3DL1/metabolism, Receptors, KIR3DL2/metabolism",
author = "Cristina Capittini and Giacomo Emmi and Savina Mannarino and Grazia Bossi and Dellepiane, {Rosa Maria} and Patrizia Salice and Pietrogrande, {Maria Cristina} and Annamaria Pasi and {De Silvestri}, Annalisa and Carmine Tinelli and Miryam Martinetti",
note = "{\circledC} 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",
year = "2018",
month = "3",
doi = "10.1002/eji.201747226",
language = "English",
volume = "48",
pages = "543--545",
journal = "European Journal of Immunology",
issn = "0014-2980",
publisher = "wiley",
number = "3",

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TY - JOUR

T1 - An immune-molecular hypothesis supporting infectious aetiopathogenesis of Kawasaki disease in children

AU - Capittini, Cristina

AU - Emmi, Giacomo

AU - Mannarino, Savina

AU - Bossi, Grazia

AU - Dellepiane, Rosa Maria

AU - Salice, Patrizia

AU - Pietrogrande, Maria Cristina

AU - Pasi, Annamaria

AU - De Silvestri, Annalisa

AU - Tinelli, Carmine

AU - Martinetti, Miryam

N1 - © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

PY - 2018/3

Y1 - 2018/3

N2 - The competitive binding between CpG-ODN (single-stranded DNA from pathogens) and HLA-B and HLA-A ligands for the inhibitory Killer Immunoglobulin-like Receptors (KIR)3DL1/2 may lead to possible hypo-sensing of pathogens and ineffective clearance. We observed an overabundance of HLA ligands for inhibitory KIR with three domains in KD subjects.

AB - The competitive binding between CpG-ODN (single-stranded DNA from pathogens) and HLA-B and HLA-A ligands for the inhibitory Killer Immunoglobulin-like Receptors (KIR)3DL1/2 may lead to possible hypo-sensing of pathogens and ineffective clearance. We observed an overabundance of HLA ligands for inhibitory KIR with three domains in KD subjects.

KW - Child

KW - Communicable Diseases/complications

KW - HLA Antigens/genetics

KW - Humans

KW - Immunogenetic Phenomena

KW - Ligands

KW - Models, Immunological

KW - Mucocutaneous Lymph Node Syndrome/etiology

KW - Oligodeoxyribonucleotides/immunology

KW - Receptors, KIR3DL1/metabolism

KW - Receptors, KIR3DL2/metabolism

U2 - 10.1002/eji.201747226

DO - 10.1002/eji.201747226

M3 - Article

C2 - 29193035

VL - 48

SP - 543

EP - 545

JO - European Journal of Immunology

JF - European Journal of Immunology

SN - 0014-2980

IS - 3

ER -