An immune-molecular hypothesis supporting infectious aetiopathogenesis of Kawasaki disease in children

Cristina Capittini, Giacomo Emmi, Savina Mannarino, Grazia Bossi, Rosa Maria Dellepiane, Patrizia Salice, Maria Cristina Pietrogrande, Annamaria Pasi, Annalisa De Silvestri, Carmine Tinelli, Miryam Martinetti

Research output: Contribution to journalArticle

Abstract

The competitive binding between CpG-ODN (single-stranded DNA from pathogens) and HLA-B and HLA-A ligands for the inhibitory Killer Immunoglobulin-like Receptors (KIR)3DL1/2 may lead to possible hypo-sensing of pathogens and ineffective clearance. We observed an overabundance of HLA ligands for inhibitory KIR with three domains in KD subjects.

Original languageEnglish
Pages (from-to)543-545
Number of pages3
JournalEuropean Journal of Immunology
Volume48
Issue number3
DOIs
Publication statusPublished - Mar 2018

Keywords

  • Child
  • Communicable Diseases/complications
  • HLA Antigens/genetics
  • Humans
  • Immunogenetic Phenomena
  • Ligands
  • Models, Immunological
  • Mucocutaneous Lymph Node Syndrome/etiology
  • Oligodeoxyribonucleotides/immunology
  • Receptors, KIR3DL1/metabolism
  • Receptors, KIR3DL2/metabolism

Fingerprint Dive into the research topics of 'An immune-molecular hypothesis supporting infectious aetiopathogenesis of Kawasaki disease in children'. Together they form a unique fingerprint.

Cite this