An immunoglobulin light chain from a lupus-prone mouse induces autoantibodies in normal mice

A. Puccetti, T. Koizumi, P. Migliorini, J. Andre-Schwartz, K. J. Barrett, R. S. Schwartz

Research output: Contribution to journalArticlepeer-review

Abstract

Autoantibodies against the 70-kD U1 RNP nucleoprotein autoantigen and DNA were elicited in normal BALB/c mice with a purified Ig light chain. This light chain, derived from a lupus-prone MRL-lpr/lpr mouse, has two distinctive properties: it contains an idiotypic marker recognized by a monoclonal MRL-lpr/lpr anti-snRNP autoantibody, and the amino acid sequence of its third hypervariable region (CDR3) is homologous to a sequence in an antigenic region of the 70-kD U1 RNP polypeptide. The results demonstrate that an Ig idiotype that mimics an autoantigen can induce autoimmunization.

Original languageEnglish
Pages (from-to)1919-1930
Number of pages12
JournalJournal of Experimental Medicine
Volume171
Issue number6
DOIs
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Immunology

Fingerprint

Dive into the research topics of 'An immunoglobulin light chain from a lupus-prone mouse induces autoantibodies in normal mice'. Together they form a unique fingerprint.

Cite this