An immunoglobulin light chain from a lupus-prone mouse induces autoantibodies in normal mice

A. Puccetti, T. Koizumi, P. Migliorini, J. Andre-Schwartz, K. J. Barrett, R. S. Schwartz

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Autoantibodies against the 70-kD U1 RNP nucleoprotein autoantigen and DNA were elicited in normal BALB/c mice with a purified Ig light chain. This light chain, derived from a lupus-prone MRL-lpr/lpr mouse, has two distinctive properties: it contains an idiotypic marker recognized by a monoclonal MRL-lpr/lpr anti-snRNP autoantibody, and the amino acid sequence of its third hypervariable region (CDR3) is homologous to a sequence in an antigenic region of the 70-kD U1 RNP polypeptide. The results demonstrate that an Ig idiotype that mimics an autoantigen can induce autoimmunization.

Original languageEnglish
Pages (from-to)1919-1930
Number of pages12
JournalJournal of Experimental Medicine
Volume171
Issue number6
DOIs
Publication statusPublished - 1990

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Immunoglobulin Light Chains
Autoantigens
Autoantibodies
Small Nuclear Ribonucleoproteins
Light
Nucleoproteins
Amino Acid Sequence
Peptides
DNA

ASJC Scopus subject areas

  • Immunology

Cite this

Puccetti, A., Koizumi, T., Migliorini, P., Andre-Schwartz, J., Barrett, K. J., & Schwartz, R. S. (1990). An immunoglobulin light chain from a lupus-prone mouse induces autoantibodies in normal mice. Journal of Experimental Medicine, 171(6), 1919-1930. https://doi.org/10.1084/jem.171.6.1919

An immunoglobulin light chain from a lupus-prone mouse induces autoantibodies in normal mice. / Puccetti, A.; Koizumi, T.; Migliorini, P.; Andre-Schwartz, J.; Barrett, K. J.; Schwartz, R. S.

In: Journal of Experimental Medicine, Vol. 171, No. 6, 1990, p. 1919-1930.

Research output: Contribution to journalArticle

Puccetti, A, Koizumi, T, Migliorini, P, Andre-Schwartz, J, Barrett, KJ & Schwartz, RS 1990, 'An immunoglobulin light chain from a lupus-prone mouse induces autoantibodies in normal mice', Journal of Experimental Medicine, vol. 171, no. 6, pp. 1919-1930. https://doi.org/10.1084/jem.171.6.1919
Puccetti, A. ; Koizumi, T. ; Migliorini, P. ; Andre-Schwartz, J. ; Barrett, K. J. ; Schwartz, R. S. / An immunoglobulin light chain from a lupus-prone mouse induces autoantibodies in normal mice. In: Journal of Experimental Medicine. 1990 ; Vol. 171, No. 6. pp. 1919-1930.
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