An improved neutron autoradiography set-up for 10B concentration measurements in biological samples

Ian Postuma, Silva Bortolussi, Nicoletta Protti, Francesca Ballarini, Piero Bruschi, Laura Ciani, Sandra Ristori, Luigi Panza, Cinzia Ferrari, Laura Cansolino, Saverio Altieri

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: Boron Neutron Capture Therapy (BNCT) is a binary hadrontherapy which exploits the neutron capture reaction in boron, together with a selective uptake of boronated substances by the neoplastic tissue. There is increasing evidence that future improvements in clinical BNCT will be triggered by the discovery of new boronated compounds, with higher selectivity for the tumor with respect to clinically used sodium borocaptate (BSH) and boronophenylalanine (BPA). Background: Therefore, a 10B quantification technique for biological samples is needed in order to evaluate the performance of new boronated formulations. Materials and methods: This article describes an improved neutron autoradiography set-up employing radiation sensitive films where the latent tracks are made visible by proper etching conditions. Results: Calibration curves for both liquid and tissue samples were obtained. Conclusions: The obtained calibration curves were adopted to set-up a mechanism to point out boron concentration in the whole sample.

Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalReports of Practical Oncology and Radiotherapy
Volume21
Issue number2
DOIs
Publication statusPublished - Mar 1 2016

Keywords

  • Boron concentration
  • Boron Neutron Capture Therapy
  • CR-39
  • Neutron autoradiography

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

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