An in vitro and in vivo comparison of the effect of stevia rebaudiana extracts on different caries-related variables: A randomized controlled trial pilot study

E. Brambilla, M. G. Cagetti, A. Ionescu, G. Campus, P. Lingström

Research output: Contribution to journalArticle

Abstract

The effect of Stevia extracts on in vitro Streptococcus mutans biofilm formation and in vivo plaque pH was evaluated in this paper. Three 10% solutions containing stevioside, rebaudioside A or sucrose were prepared. MTT assay was used to evaluate microbiological counts in vitro. Twenty volunteers rinsed for 1 min with each solutions, and plaque pH was measured at 7 time points after each rinse. Higher in vitro S. mutans biofilm formation was observed in sucrose solution (p <0.01). After 5, 10, 15 and 30 min, the sucrose in vivo rinse produced a statistically significantly lower pH value compared to the Stevia extracts (F = 99.45, p <0.01).Stevia extracts can be considered nonacidogenic.

Original languageEnglish
Pages (from-to)19-23
Number of pages5
JournalCaries Research
Volume48
Issue number1
DOIs
Publication statusPublished - Jan 2014

Keywords

  • Caries
  • Plaque pH
  • Rebaudioside A
  • Stevioside

ASJC Scopus subject areas

  • Dentistry(all)
  • Medicine(all)

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