An increase in bronchial responsiveness is associated with continuing or restarting smoking

Susan Chinn, Deborah Jarvis, Christina M. Luczynska, Ursula Ackermann-Liebrich, Josep M. Antó, Isa Cerveri, Roberto De Marco, Thorarinn Gislason, Joachim Heinrich, Christer Janson, Nino Künzli, Bénédicte Leynaert, Françoise Neukirch, Jan P. Schouten, Jordi Sunyer, Cecilie Svanes, Matthias Wjst, Peter G. Burney

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Rationale: Bronchial responsiveness (BHR) has been found to be associated with smoking, atopy, and lower lung function in cross-sectional studies, but there is little information on determinants of change in adults. Objectives: To analyze change in bronchial responsiveness in an international longitudinal community study. Methods: The study was performed in 3,993 participants in the European Community Respiratory Health Survey who had bronchial responsiveness measured in 1991-1993, when aged 20 to 44 yr, and in 1998-2002. Measurements: Bronchial responsiveness was assessed by methacholine challenge. Serum samples were tested for total IgE, and for specific IgE to four common allergens. Smoking information was obtained from detailed administered questionnaires. Change in bronchial responsiveness was analyzed by change in IgE sensitization, smoking, and lung function, with tests of interaction terms with age and sex. Main Results: Continuing and restarting smokers had increasing bronchial responsiveness, approximately equivalent to a mean reduction in PD20 of 0.68 and 0.75 doubling doses, respectively, over 10 yr, in addition to a small increase explained by decline in FEV1. No other risk factor for change in bronchial responsiveness was identified. Conclusions: Smoking is a risk factor for increasing bronchial responsiveness over and above the effect of decreasing lung function. Neither baseline IgE sensitization nor change in sensitization was shown to be a risk factor for increasing BHR, the latter possibly due to little overall increase or decrease in sensitization.

Original languageEnglish
Pages (from-to)956-961
Number of pages6
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume172
Issue number8
DOIs
Publication statusPublished - Oct 15 2005

Fingerprint

Immunoglobulin E
Smoking
Lung
Methacholine Chloride
Respiratory Function Tests
European Union
Health Surveys
Allergens
Longitudinal Studies
Cross-Sectional Studies
Serum

Keywords

  • Asthma
  • Atopy
  • Bronchial hyperreactivity
  • Chronic obstructive
  • Immunoglobulin E
  • Pulmonary disease

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

An increase in bronchial responsiveness is associated with continuing or restarting smoking. / Chinn, Susan; Jarvis, Deborah; Luczynska, Christina M.; Ackermann-Liebrich, Ursula; Antó, Josep M.; Cerveri, Isa; De Marco, Roberto; Gislason, Thorarinn; Heinrich, Joachim; Janson, Christer; Künzli, Nino; Leynaert, Bénédicte; Neukirch, Françoise; Schouten, Jan P.; Sunyer, Jordi; Svanes, Cecilie; Wjst, Matthias; Burney, Peter G.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 172, No. 8, 15.10.2005, p. 956-961.

Research output: Contribution to journalArticle

Chinn, S, Jarvis, D, Luczynska, CM, Ackermann-Liebrich, U, Antó, JM, Cerveri, I, De Marco, R, Gislason, T, Heinrich, J, Janson, C, Künzli, N, Leynaert, B, Neukirch, F, Schouten, JP, Sunyer, J, Svanes, C, Wjst, M & Burney, PG 2005, 'An increase in bronchial responsiveness is associated with continuing or restarting smoking', American Journal of Respiratory and Critical Care Medicine, vol. 172, no. 8, pp. 956-961. https://doi.org/10.1164/rccm.200503-323OC
Chinn, Susan ; Jarvis, Deborah ; Luczynska, Christina M. ; Ackermann-Liebrich, Ursula ; Antó, Josep M. ; Cerveri, Isa ; De Marco, Roberto ; Gislason, Thorarinn ; Heinrich, Joachim ; Janson, Christer ; Künzli, Nino ; Leynaert, Bénédicte ; Neukirch, Françoise ; Schouten, Jan P. ; Sunyer, Jordi ; Svanes, Cecilie ; Wjst, Matthias ; Burney, Peter G. / An increase in bronchial responsiveness is associated with continuing or restarting smoking. In: American Journal of Respiratory and Critical Care Medicine. 2005 ; Vol. 172, No. 8. pp. 956-961.
@article{e2cdfcbbe9dc4c77af3c57236bc82361,
title = "An increase in bronchial responsiveness is associated with continuing or restarting smoking",
abstract = "Rationale: Bronchial responsiveness (BHR) has been found to be associated with smoking, atopy, and lower lung function in cross-sectional studies, but there is little information on determinants of change in adults. Objectives: To analyze change in bronchial responsiveness in an international longitudinal community study. Methods: The study was performed in 3,993 participants in the European Community Respiratory Health Survey who had bronchial responsiveness measured in 1991-1993, when aged 20 to 44 yr, and in 1998-2002. Measurements: Bronchial responsiveness was assessed by methacholine challenge. Serum samples were tested for total IgE, and for specific IgE to four common allergens. Smoking information was obtained from detailed administered questionnaires. Change in bronchial responsiveness was analyzed by change in IgE sensitization, smoking, and lung function, with tests of interaction terms with age and sex. Main Results: Continuing and restarting smokers had increasing bronchial responsiveness, approximately equivalent to a mean reduction in PD20 of 0.68 and 0.75 doubling doses, respectively, over 10 yr, in addition to a small increase explained by decline in FEV1. No other risk factor for change in bronchial responsiveness was identified. Conclusions: Smoking is a risk factor for increasing bronchial responsiveness over and above the effect of decreasing lung function. Neither baseline IgE sensitization nor change in sensitization was shown to be a risk factor for increasing BHR, the latter possibly due to little overall increase or decrease in sensitization.",
keywords = "Asthma, Atopy, Bronchial hyperreactivity, Chronic obstructive, Immunoglobulin E, Pulmonary disease",
author = "Susan Chinn and Deborah Jarvis and Luczynska, {Christina M.} and Ursula Ackermann-Liebrich and Ant{\'o}, {Josep M.} and Isa Cerveri and {De Marco}, Roberto and Thorarinn Gislason and Joachim Heinrich and Christer Janson and Nino K{\"u}nzli and B{\'e}n{\'e}dicte Leynaert and Fran{\cc}oise Neukirch and Schouten, {Jan P.} and Jordi Sunyer and Cecilie Svanes and Matthias Wjst and Burney, {Peter G.}",
year = "2005",
month = "10",
day = "15",
doi = "10.1164/rccm.200503-323OC",
language = "English",
volume = "172",
pages = "956--961",
journal = "American Journal of Respiratory and Critical Care Medicine",
issn = "1073-449X",
publisher = "American Thoracic Society - AJRCCM",
number = "8",

}

TY - JOUR

T1 - An increase in bronchial responsiveness is associated with continuing or restarting smoking

AU - Chinn, Susan

AU - Jarvis, Deborah

AU - Luczynska, Christina M.

AU - Ackermann-Liebrich, Ursula

AU - Antó, Josep M.

AU - Cerveri, Isa

AU - De Marco, Roberto

AU - Gislason, Thorarinn

AU - Heinrich, Joachim

AU - Janson, Christer

AU - Künzli, Nino

AU - Leynaert, Bénédicte

AU - Neukirch, Françoise

AU - Schouten, Jan P.

AU - Sunyer, Jordi

AU - Svanes, Cecilie

AU - Wjst, Matthias

AU - Burney, Peter G.

PY - 2005/10/15

Y1 - 2005/10/15

N2 - Rationale: Bronchial responsiveness (BHR) has been found to be associated with smoking, atopy, and lower lung function in cross-sectional studies, but there is little information on determinants of change in adults. Objectives: To analyze change in bronchial responsiveness in an international longitudinal community study. Methods: The study was performed in 3,993 participants in the European Community Respiratory Health Survey who had bronchial responsiveness measured in 1991-1993, when aged 20 to 44 yr, and in 1998-2002. Measurements: Bronchial responsiveness was assessed by methacholine challenge. Serum samples were tested for total IgE, and for specific IgE to four common allergens. Smoking information was obtained from detailed administered questionnaires. Change in bronchial responsiveness was analyzed by change in IgE sensitization, smoking, and lung function, with tests of interaction terms with age and sex. Main Results: Continuing and restarting smokers had increasing bronchial responsiveness, approximately equivalent to a mean reduction in PD20 of 0.68 and 0.75 doubling doses, respectively, over 10 yr, in addition to a small increase explained by decline in FEV1. No other risk factor for change in bronchial responsiveness was identified. Conclusions: Smoking is a risk factor for increasing bronchial responsiveness over and above the effect of decreasing lung function. Neither baseline IgE sensitization nor change in sensitization was shown to be a risk factor for increasing BHR, the latter possibly due to little overall increase or decrease in sensitization.

AB - Rationale: Bronchial responsiveness (BHR) has been found to be associated with smoking, atopy, and lower lung function in cross-sectional studies, but there is little information on determinants of change in adults. Objectives: To analyze change in bronchial responsiveness in an international longitudinal community study. Methods: The study was performed in 3,993 participants in the European Community Respiratory Health Survey who had bronchial responsiveness measured in 1991-1993, when aged 20 to 44 yr, and in 1998-2002. Measurements: Bronchial responsiveness was assessed by methacholine challenge. Serum samples were tested for total IgE, and for specific IgE to four common allergens. Smoking information was obtained from detailed administered questionnaires. Change in bronchial responsiveness was analyzed by change in IgE sensitization, smoking, and lung function, with tests of interaction terms with age and sex. Main Results: Continuing and restarting smokers had increasing bronchial responsiveness, approximately equivalent to a mean reduction in PD20 of 0.68 and 0.75 doubling doses, respectively, over 10 yr, in addition to a small increase explained by decline in FEV1. No other risk factor for change in bronchial responsiveness was identified. Conclusions: Smoking is a risk factor for increasing bronchial responsiveness over and above the effect of decreasing lung function. Neither baseline IgE sensitization nor change in sensitization was shown to be a risk factor for increasing BHR, the latter possibly due to little overall increase or decrease in sensitization.

KW - Asthma

KW - Atopy

KW - Bronchial hyperreactivity

KW - Chronic obstructive

KW - Immunoglobulin E

KW - Pulmonary disease

UR - http://www.scopus.com/inward/record.url?scp=26944480377&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=26944480377&partnerID=8YFLogxK

U2 - 10.1164/rccm.200503-323OC

DO - 10.1164/rccm.200503-323OC

M3 - Article

C2 - 16020802

AN - SCOPUS:26944480377

VL - 172

SP - 956

EP - 961

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

IS - 8

ER -