An increased thrombin generation is detectable for at least 1 week following elective percutaneous transluminal coronary angioplasty

D. Prisco, E. Antonucci, M. Capanni, L. Chiarugi, V. Boddi, C. Giglioli, M. Comeglio, S. Fedi, G. F. Gensini, R. Abbate

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Abstract

Objective: The present prospective study was planned to investigate: (1) how long the early haemostatic changes after PTCA last and (2) if some coagulation and/or fibrinolytic parameters assessed during the first month after PTCA may be predictive of subsequent clinical recurrence. Setting: Istituto di Clinica Medica Generale e Cardiologia, University of Florence, Florence, Italy. Material and Methods: In 72 patients undergoing PTCA fibrinogen, F1+2, TAT, D-dimer and ELT were evaluated before the procedure (T1) and 2 (T2), 7 (T7) and 30 days (T30) after PTCA; PAI-1 and t-PA were assessed before PTCA and after 7 and 30 days. Follow-up angiography was performed only in patients with recurrence of ischaemia or positive ergometric tests. Results: F1+2, TAT and fibrinogen were significantly increased at T2 (P

Original languageEnglish
Pages (from-to)253-260
Number of pages8
JournalFibrinolysis and Proteolysis
Volume14
Issue number4
Publication statusPublished - 2000

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ASJC Scopus subject areas

  • Hematology

Cite this

Prisco, D., Antonucci, E., Capanni, M., Chiarugi, L., Boddi, V., Giglioli, C., Comeglio, M., Fedi, S., Gensini, G. F., & Abbate, R. (2000). An increased thrombin generation is detectable for at least 1 week following elective percutaneous transluminal coronary angioplasty. Fibrinolysis and Proteolysis, 14(4), 253-260.