An inflammatory profile correlates with decreased frequency of cytotoxic cells in coronavirus disease 2019

Research output: Contribution to journalReview articlepeer-review

Abstract

Increased production of inflammatory cytokines and myeloid-derived suppressor cells occurs in patients with coronavirus disease 2019. These inversely correlated with perforin-expressing natural killer (NK) and CD3+ T cells. We observed a lower number of perforin-expressing NK cells in intensive care unit (ICU) patients compared with non-ICU patients, suggesting an impairment of the immune cytotoxic arm as a pathogenic mechanism.

Original languageEnglish
Pages (from-to)2272-2275
Number of pages4
JournalClinical Infectious Diseases
Volume71
Issue number16
DOIs
Publication statusPublished - Oct 15 2020

Keywords

  • COVID-19
  • cytotoxic cells
  • inflammation
  • MDSC
  • NK cells

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'An inflammatory profile correlates with decreased frequency of cytotoxic cells in coronavirus disease 2019'. Together they form a unique fingerprint.

Cite this