An inflammatory profile correlates with decreased frequency of cytotoxic cells in coronavirus disease 2019: Clinical Infectious Diseases

Research output: Contribution to journalArticlepeer-review

Abstract

Increased production of inflammatory cytokines and myeloid-derived suppressor cells occurs in patients with coronavirus disease 2019. These inversely correlated with perforin-expressing natural killer (NK) and CD3+ T cells. We observed a lower number of perforin-expressing NK cells in intensive care unit (ICU) patients compared with non-ICU patients, suggesting an impairment of the immune cytotoxic arm as a pathogenic mechanism. © The Author(s) 2020.
Original languageEnglish
Pages (from-to)2272-2275
Number of pages4
JournalClin. Infect. Dis.
Volume71
Issue number16
DOIs
Publication statusPublished - 2020

Keywords

  • COVID-19
  • cytotoxic cells
  • inflammation
  • MDSC
  • NK cells
  • cytokine
  • perforin
  • aged
  • blood
  • complication
  • cytotoxic T lymphocyte
  • female
  • human
  • immunology
  • intensive care unit
  • Italy
  • lymphocyte activation
  • male
  • middle aged
  • natural killer cell
  • Aged
  • Cytokines
  • Female
  • Humans
  • Inflammation
  • Intensive Care Units
  • Killer Cells, Natural
  • Lymphocyte Activation
  • Male
  • Middle Aged
  • Perforin
  • SARS-CoV-2
  • T-Lymphocytes, Cytotoxic

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