An inflammatory profile correlates with decreased frequency of cytotoxic cells in coronavirus disease 2019: Clinical Infectious Diseases

V. Bordoni; A. Sacchi; E. Cimini; S. Notari; G. Grassi; E. Tartaglia; R. Casetti; M.L. Giancola; N. Bevilacqua; M. Maeurer; A. Zumla; F. Locatelli; F. De Benedetti; F. Palmieri; L. Marchioni; M.R. Capobianchi; G. D'Offizi; N. Petrosillo; A. Antinori; E. Nicastri; G. Ippolito; C. Agrati

doi:10.1093/cid/ciaa577

An inflammatory profile correlates with decreased frequency of cytotoxic cells in coronavirus disease 2019: Clinical Infectious Diseases

V. Bordoni, A. Sacchi, E. Cimini, S. Notari, G. Grassi, E. Tartaglia, R. Casetti, M.L. Giancola, N. Bevilacqua, M. Maeurer, A. Zumla, F. Locatelli, F. De Benedetti, F. Palmieri, L. Marchioni, M.R. Capobianchi, G. D'Offizi, N. Petrosillo, A. Antinori, E. NicastriG. Ippolito, C. Agrati

Research output: Contribution to journal › Article › peer-review

Abstract

Increased production of inflammatory cytokines and myeloid-derived suppressor cells occurs in patients with coronavirus disease 2019. These inversely correlated with perforin-expressing natural killer (NK) and CD3+ T cells. We observed a lower number of perforin-expressing NK cells in intensive care unit (ICU) patients compared with non-ICU patients, suggesting an impairment of the immune cytotoxic arm as a pathogenic mechanism. © The Author(s) 2020.

Original language	English
Pages (from-to)	2272-2275
Number of pages	4
Journal	Clin. Infect. Dis.
Volume	71
Issue number	16
DOIs	https://doi.org/10.1093/cid/ciaa577
Publication status	Published - 2020

Keywords

COVID-19
cytotoxic cells
inflammation
MDSC
NK cells
cytokine
perforin
aged
blood
complication
cytotoxic T lymphocyte
female
human
immunology
intensive care unit
Italy
lymphocyte activation
male
middle aged
natural killer cell
Aged
Cytokines
Female
Humans
Inflammation
Intensive Care Units
Killer Cells, Natural
Lymphocyte Activation
Male
Middle Aged
Perforin
SARS-CoV-2
T-Lymphocytes, Cytotoxic

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10.1093/cid/ciaa577

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An inflammatory profile correlates with decreased frequency of cytotoxic cells in coronavirus disease 2019 : Clinical Infectious Diseases. / Bordoni, V.; Sacchi, A.; Cimini, E.; Notari, S.; Grassi, G.; Tartaglia, E.; Casetti, R.; Giancola, M.L.; Bevilacqua, N.; Maeurer, M.; Zumla, A.; Locatelli, F.; De Benedetti, F.; Palmieri, F.; Marchioni, L.; Capobianchi, M.R.; D'Offizi, G.; Petrosillo, N.; Antinori, A.; Nicastri, E.; Ippolito, G.; Agrati, C.

In: Clin. Infect. Dis., Vol. 71, No. 16, 2020, p. 2272-2275.

Research output: Contribution to journal › Article › peer-review

Bordoni, V. ; Sacchi, A. ; Cimini, E. ; Notari, S. ; Grassi, G. ; Tartaglia, E. ; Casetti, R. ; Giancola, M.L. ; Bevilacqua, N. ; Maeurer, M. ; Zumla, A. ; Locatelli, F. ; De Benedetti, F. ; Palmieri, F. ; Marchioni, L. ; Capobianchi, M.R. ; D'Offizi, G. ; Petrosillo, N. ; Antinori, A. ; Nicastri, E. ; Ippolito, G. ; Agrati, C. / An inflammatory profile correlates with decreased frequency of cytotoxic cells in coronavirus disease 2019 : Clinical Infectious Diseases. In: Clin. Infect. Dis. 2020 ; Vol. 71, No. 16. pp. 2272-2275.

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abstract = "Increased production of inflammatory cytokines and myeloid-derived suppressor cells occurs in patients with coronavirus disease 2019. These inversely correlated with perforin-expressing natural killer (NK) and CD3+ T cells. We observed a lower number of perforin-expressing NK cells in intensive care unit (ICU) patients compared with non-ICU patients, suggesting an impairment of the immune cytotoxic arm as a pathogenic mechanism. {\textcopyright} The Author(s) 2020.",

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author = "V. Bordoni and A. Sacchi and E. Cimini and S. Notari and G. Grassi and E. Tartaglia and R. Casetti and M.L. Giancola and N. Bevilacqua and M. Maeurer and A. Zumla and F. Locatelli and {De Benedetti}, F. and F. Palmieri and L. Marchioni and M.R. Capobianchi and G. D'Offizi and N. Petrosillo and A. Antinori and E. Nicastri and G. Ippolito and C. Agrati",

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AU - Notari, S.

AU - Grassi, G.

AU - Tartaglia, E.

AU - Casetti, R.

AU - Giancola, M.L.

AU - Bevilacqua, N.

AU - Maeurer, M.

AU - Zumla, A.

AU - Locatelli, F.

AU - De Benedetti, F.

AU - Palmieri, F.

AU - Marchioni, L.

AU - Capobianchi, M.R.

AU - D'Offizi, G.

AU - Petrosillo, N.

AU - Antinori, A.

AU - Nicastri, E.

AU - Ippolito, G.

AU - Agrati, C.

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