Abstract
Increased production of inflammatory cytokines and myeloid-derived suppressor cells occurs in patients with coronavirus disease 2019. These inversely correlated with perforin-expressing natural killer (NK) and CD3+ T cells. We observed a lower number of perforin-expressing NK cells in intensive care unit (ICU) patients compared with non-ICU patients, suggesting an impairment of the immune cytotoxic arm as a pathogenic mechanism. © The Author(s) 2020.
Original language | English |
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Pages (from-to) | 2272-2275 |
Number of pages | 4 |
Journal | Clin. Infect. Dis. |
Volume | 71 |
Issue number | 16 |
DOIs | |
Publication status | Published - 2020 |
Keywords
- COVID-19
- cytotoxic cells
- inflammation
- MDSC
- NK cells
- cytokine
- perforin
- aged
- blood
- complication
- cytotoxic T lymphocyte
- female
- human
- immunology
- intensive care unit
- Italy
- lymphocyte activation
- male
- middle aged
- natural killer cell
- Aged
- Cytokines
- Female
- Humans
- Inflammation
- Intensive Care Units
- Killer Cells, Natural
- Lymphocyte Activation
- Male
- Middle Aged
- Perforin
- SARS-CoV-2
- T-Lymphocytes, Cytotoxic