An integrate-and-fire model of a cerebellar granule cell

Michele Bezzi, Thierry Nieus, Olivier J M Coenen, Egidio D'Angelo

Research output: Contribution to journalArticle

Abstract

We present a simple spiking model that extends the classical integrate-and-fire neuron to reproduce the different dynamical behaviors observed in cerebellar granule cells. The model is two dimensional: in addition to the membrane potential V, we consider a gating variable that models a slow K + current. This current plays a major role in generating the rhythmic behavior and resonance in the model. Despite its simplicity this model is able to reproduce most of the properties observed in granule cell recordings and in numerical simulations with high-dimensional Hodgkin-Huxley models.

Original languageEnglish
Pages (from-to)593-598
Number of pages6
JournalNeurocomputing
Volume58-60
DOIs
Publication statusPublished - Jun 2004

Keywords

  • Cerebellum
  • Integrate-and-fire neuron
  • Resonance

ASJC Scopus subject areas

  • Artificial Intelligence
  • Cellular and Molecular Neuroscience

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