An integrated psychological strategy for advanced colorectal cancer patients

Patrizia Pugliese, Maria Perrone, Enrica Nisi, Carlo Garufi, Diana Giannarelli, Andrew Bottomley, Edmondo Terzoli

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: There is evidence regarding the usefulness of psychosocial intervention to improve health related quality of life (HRQOL) in adult cancer patients. The aim of this report is to describe an integrated approach and to evaluate its feasibility in routine clinical practice in 98 advanced colorectal cancer (ACC) patients during chronomodulated chemotherapy. Methods: A prospective non-randomised design was developed and applied in a cancer outpatient setting. The intervention consisted of an integrated approach, whereby the psycho-oncologist had an active role in the health care team with the physician and routinely included psychological understanding in the medical treatment program. The psychological evaluation assessed: a) adaptation, awareness, psychopathological disorders through a psychodynamic interview; b) anxiety and depression using the HAD scale; c) subjective perception of care quality through a structured interview and d) HRQOL evaluation assessment with the EORTC QLQ C30. Outcomes data were collected before and after 18 weeks of chemotherapy. Results: After 18 weeks of chemotherapy a significant improvement of adaptation and awareness was observed. The HADs results showed a significant decrease in anxiety when compared to pre-treatment. The structured interview showed a significant increase of patients who positively experienced the impact of medical treatment on HRQOL, anxiety, depression, interpersonal relationships, free-time and who positively experienced the care quality. Indeed, a majority of patients positively experienced the team relationship modality during the whole treatment. All scales on the EORTC questionnaire remained unchanged during the entire treatment. Conclusion: Our results suggest that it is feasible to carry out an integrated approach during chemotherapy. These results seem to support the integrated approach as a tool in aiding advanced colorectal cancer patients' ability to cope with their diagnosis and treatment although an appropriately designed study is required to confirm this.

Original languageEnglish
Article number9
JournalHealth and Quality of Life Outcomes
Volume4
DOIs
Publication statusPublished - Feb 6 2006

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Colorectal Neoplasms
Psychology
Drug Therapy
Anxiety
Quality of Health Care
Quality of Life
Interviews
Therapeutics
Depression
Patient Care Team
Aptitude
Neoplasms
Outpatients
Physicians

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

An integrated psychological strategy for advanced colorectal cancer patients. / Pugliese, Patrizia; Perrone, Maria; Nisi, Enrica; Garufi, Carlo; Giannarelli, Diana; Bottomley, Andrew; Terzoli, Edmondo.

In: Health and Quality of Life Outcomes, Vol. 4, 9, 06.02.2006.

Research output: Contribution to journalArticle

Pugliese, Patrizia ; Perrone, Maria ; Nisi, Enrica ; Garufi, Carlo ; Giannarelli, Diana ; Bottomley, Andrew ; Terzoli, Edmondo. / An integrated psychological strategy for advanced colorectal cancer patients. In: Health and Quality of Life Outcomes. 2006 ; Vol. 4.
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