TY - JOUR
T1 - An integrated view of humoral innate immunity
T2 - Pentraxins as a paradigm
AU - Bottazzi, Barbara
AU - Doni, Andrea
AU - Garlanda, Cecilia
AU - Mantovani, Alberto
PY - 2010/4/23
Y1 - 2010/4/23
N2 - The innate immune system consists of a cellular and a humoral arm. Pentraxins (e.g., the short pentraxin C reactive protein and the long pentraxin PTX3) are key components of the humoral arm of innate immunity which also includes complement components, collectins, and ficolins. In response to microorganisms and tissue damage, neutrophils, macrophages, and dendritic cells are major sources of fluid-phase pattern-recognition molecules (PRMs) belonging to different molecular classes. Humoral PRMs in turn interact with and regulate cellular effectors. Effector mechanisms of the humoral innate immune system include activation and regulation of the complement cascade; agglutination and neutralization; facilitation of recognition via cellular receptors (opsonization); and regulation of inflammation. Thus, the humoral arm of innate immunity is an integrated system consisting of different molecules and sharing functional outputs with antibodies.
AB - The innate immune system consists of a cellular and a humoral arm. Pentraxins (e.g., the short pentraxin C reactive protein and the long pentraxin PTX3) are key components of the humoral arm of innate immunity which also includes complement components, collectins, and ficolins. In response to microorganisms and tissue damage, neutrophils, macrophages, and dendritic cells are major sources of fluid-phase pattern-recognition molecules (PRMs) belonging to different molecular classes. Humoral PRMs in turn interact with and regulate cellular effectors. Effector mechanisms of the humoral innate immune system include activation and regulation of the complement cascade; agglutination and neutralization; facilitation of recognition via cellular receptors (opsonization); and regulation of inflammation. Thus, the humoral arm of innate immunity is an integrated system consisting of different molecules and sharing functional outputs with antibodies.
KW - C reactive protein
KW - Collectins
KW - Complement
KW - Ficolins
KW - Phagocytes
KW - Serum amyloid P component
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U2 - 10.1146/annurev-immunol-030409-101305
DO - 10.1146/annurev-immunol-030409-101305
M3 - Article
C2 - 19968561
AN - SCOPUS:77952316540
VL - 28
SP - 157
EP - 183
JO - Annual Review of Immunology
JF - Annual Review of Immunology
SN - 0732-0582
ER -