An International Case-Control Study of Maternal Diet During Pregnancy and Childhood Brain Tumor Risk: A Histology-Specific Analysis by Food Group

Janice M. Pogoda, Susan Preston-Martin, Geoffrey Howe, Flora Lubin, Beth A. Mueller, Elizabeth A. Holly, Graziella Filippini, Raphael Peris-Bonet, Margaret R E Mccredie, Sylvaine Cordier, Won Choi

Research output: Contribution to journalArticle

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Abstract

Purpose: Maternal dietary data from an international collaborative case-control study on childhood brain tumors were used to evaluate associations between histology-specific risk and consumption of specific food groups during pregnancy. Methods: Nine study centers from seven countries contributed 1218 cases and 2223 controls. Most cases were diagnosed between 1982 and 1992 and ranged in age from 0 to 19 years. Dietary consumption was measured as average grams per day. Results: Foods generally associated with increased risk were cured meats, eggs/dairy, and oil products; foods generally associated with decreased risk were yellow-orange vegetables, fresh fish, and grains. The cured meat association was specific to astrocytomas (odds ratio [OR] range = 1.8-2.5 across astrocytoma subtypes for 4th vs. 1st quartile of consumption, p trends ≤ 0.03) and ependymomas (OR, 2.0; 95% confidence interval (CI), 0.4-2.9 for 4th vs. 1st quartile; p trend = 0.03) and was similar in magnitude to previously reported ORs relating maternal cured meat consumption to increased astroglial risk. Other histology-specific associations were decreased risk of anaplastic astrocytomas from cruciferous vegetables (OR, 0.4; 95% CI, 0.3-0.7 for 4th vs. 1st quartile; p trend <0.0001), decreased risk of astroglial tumors from fresh fish (OR, 0.6; 95% CI, 0.5-0.9 for 4th vs. 1st quartile; p trend = 0.008), and increased risk of medulloblastoma from oil products (OR, 1.5; 95% CI, 1.0-2.2 for 4th vs. 1st quartile; p trend = 0.005). Conclusions: These results suggest the need for dietary analysis not only by brain tumor histology, but also by specific foods within a broad food group.

Original languageEnglish
Pages (from-to)148-160
Number of pages13
JournalAnnals of Epidemiology
Volume19
Issue number3
DOIs
Publication statusPublished - Mar 2009

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Food Analysis
Brain Neoplasms
Case-Control Studies
Histology
Mothers
Diet
Pregnancy
Odds Ratio
Astrocytoma
Food
Confidence Intervals
Meat
Vegetables
Fishes
Ependymoma
Medulloblastoma
Dairy Products
Oils

Keywords

  • Brain Tumors
  • Childhood Neoplasms
  • Cured Meat Products
  • Diet
  • N-Nitroso Compounds
  • Vegetables

ASJC Scopus subject areas

  • Epidemiology

Cite this

An International Case-Control Study of Maternal Diet During Pregnancy and Childhood Brain Tumor Risk : A Histology-Specific Analysis by Food Group. / Pogoda, Janice M.; Preston-Martin, Susan; Howe, Geoffrey; Lubin, Flora; Mueller, Beth A.; Holly, Elizabeth A.; Filippini, Graziella; Peris-Bonet, Raphael; Mccredie, Margaret R E; Cordier, Sylvaine; Choi, Won.

In: Annals of Epidemiology, Vol. 19, No. 3, 03.2009, p. 148-160.

Research output: Contribution to journalArticle

Pogoda, JM, Preston-Martin, S, Howe, G, Lubin, F, Mueller, BA, Holly, EA, Filippini, G, Peris-Bonet, R, Mccredie, MRE, Cordier, S & Choi, W 2009, 'An International Case-Control Study of Maternal Diet During Pregnancy and Childhood Brain Tumor Risk: A Histology-Specific Analysis by Food Group', Annals of Epidemiology, vol. 19, no. 3, pp. 148-160. https://doi.org/10.1016/j.annepidem.2008.12.011
Pogoda, Janice M. ; Preston-Martin, Susan ; Howe, Geoffrey ; Lubin, Flora ; Mueller, Beth A. ; Holly, Elizabeth A. ; Filippini, Graziella ; Peris-Bonet, Raphael ; Mccredie, Margaret R E ; Cordier, Sylvaine ; Choi, Won. / An International Case-Control Study of Maternal Diet During Pregnancy and Childhood Brain Tumor Risk : A Histology-Specific Analysis by Food Group. In: Annals of Epidemiology. 2009 ; Vol. 19, No. 3. pp. 148-160.
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abstract = "Purpose: Maternal dietary data from an international collaborative case-control study on childhood brain tumors were used to evaluate associations between histology-specific risk and consumption of specific food groups during pregnancy. Methods: Nine study centers from seven countries contributed 1218 cases and 2223 controls. Most cases were diagnosed between 1982 and 1992 and ranged in age from 0 to 19 years. Dietary consumption was measured as average grams per day. Results: Foods generally associated with increased risk were cured meats, eggs/dairy, and oil products; foods generally associated with decreased risk were yellow-orange vegetables, fresh fish, and grains. The cured meat association was specific to astrocytomas (odds ratio [OR] range = 1.8-2.5 across astrocytoma subtypes for 4th vs. 1st quartile of consumption, p trends ≤ 0.03) and ependymomas (OR, 2.0; 95{\%} confidence interval (CI), 0.4-2.9 for 4th vs. 1st quartile; p trend = 0.03) and was similar in magnitude to previously reported ORs relating maternal cured meat consumption to increased astroglial risk. Other histology-specific associations were decreased risk of anaplastic astrocytomas from cruciferous vegetables (OR, 0.4; 95{\%} CI, 0.3-0.7 for 4th vs. 1st quartile; p trend <0.0001), decreased risk of astroglial tumors from fresh fish (OR, 0.6; 95{\%} CI, 0.5-0.9 for 4th vs. 1st quartile; p trend = 0.008), and increased risk of medulloblastoma from oil products (OR, 1.5; 95{\%} CI, 1.0-2.2 for 4th vs. 1st quartile; p trend = 0.005). Conclusions: These results suggest the need for dietary analysis not only by brain tumor histology, but also by specific foods within a broad food group.",
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