An international perspective on hospitalized patients with viral community-acquired pneumonia

Dejan Radovanovic, Giovanni Sotgiu, Mateja Jankovic, Padukudru Anand Mahesh, Pedro Jorge Marcos, Mohamed I. Abdalla, Marta Francesca Di Pasquale, Andrea Gramegna, Silvia Terraneo, Francesco Blasi, Pierachille Santus, Stefano Aliberti, Luis F. Reyes, Marcos I. Restrepo, Patricia Karina Aruj, Silvia Attorri, Enrique Barimboim, Juan Pablo Caeiro, María I. Garzón, Victor Hugo CambursanoAdrian Ceccato, Julio Chertcoff, Ariel Cordon Díaz, Lautaro de Vedia, Maria Cristina Ganaha, Sandra Lambert, Gustavo Lopardo, Carlos M. Luna, Alessio Gerardo Malberti, Nora Morcillo, Silvina Tartara, Claudia Pensotti, Betiana Pereyra, Pablo Gustavo Scapellato, Juan Pablo Stagnaro, Sonali Shah, Felix Lötsch, Florian Thalhammer, Kurt Anseeuw, Camille A. Francois, Eva Van Braeckel, Jean Louis Vincent, Marcel Zannou Djimon, Simone Aranha Nouér, Peter Chipev, Milena Encheva, Darina Miteva, Diana Petkova, Adamou Dodo Balkissou, Eric Walter Pefura Yone

Research output: Contribution to journalArticle

Abstract

© 2018 European Federation of Internal Medicine Background: Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP. Methods: Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP. Testing frequency, prevalence of viral CAP and treatment with oseltamivir were assessed among patients who underwent a viral swab. Univariate and multivariate analysis was used to evaluate risk factors. Results: 553 (14.9%) patients with CAP underwent nasal swab. Viral CAP was diagnosed in 157 (28.4%) patients. Influenza virus was isolated in 80.9% of cases. Testing frequency and viral CAP prevalence were inhomogeneous across the participating centers. Obesity (OR 1.59, 95%CI: 1.01–2.48; p = 0.043) and need for invasive mechanical ventilation (OR 1.62, 95%CI: 1.02–2.56; p = 0.040) were independently associated with viral CAP. Prevalence of empirical treatment with oseltamivir was 5.1%. Conclusion: In an international scenario, testing frequency for viruses in CAP is very low. The most common cause of viral CAP is Influenza virus. Obesity and need for invasive ventilation represent independent risk factors for viral CAP. Adherence to recommendations for treatment with oseltamivir is poor.
Original languageEnglish
Pages (from-to)54-70
JournalEuropean Journal of Internal Medicine
Volume60
DOIs
Publication statusPublished - 2019

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Keywords

  • Community acquired pneumonia
  • Influenza
  • Oseltamivir
  • Testing
  • Viral pneumonia
  • Viral swab

Cite this

Radovanovic, D., Sotgiu, G., Jankovic, M., Mahesh, P. A., Marcos, P. J., Abdalla, M. I., Di Pasquale, M. F., Gramegna, A., Terraneo, S., Blasi, F., Santus, P., Aliberti, S., Reyes, L. F., Restrepo, M. I., Aruj, P. K., Attorri, S., Barimboim, E., Caeiro, J. P., Garzón, M. I., ... Pefura Yone, E. W. (2019). An international perspective on hospitalized patients with viral community-acquired pneumonia. European Journal of Internal Medicine, 60, 54-70. https://doi.org/10.1016/j.ejim.2018.10.020