An intersectional gene regulatory strategy defines subclass diversity of C. Elegans motor neurons

P Kratsios, SY Kerk, C Catela, J Liang, B Vidal, EA Bayer, W Feng, ED De La Cruz, L Croci, GG Consalez, K Mizumoto, O Hobert

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Abstract

A core principle of nervous system organization is the diversification of neuron classes into subclasses that share large sets of features but differ in select traits. We describe here a molecular mechanism necessary for motor neurons to acquire subclass-specific traits in the nematode Caenorhabditis elegans. Cholinergic motor neuron classes of the ventral nerve cord can be subdivided into subclasses al ong the anterior-posterior (A-P) axis based on synaptic connectivity patterns and molecular features. The conserved COE-type terminal selector UNC-3 not only controls the expression of traits shared by all members of a neuron class, but is also required for subclass-specific traits expressed along the A-P axis. UNC-3, which is not regionally restricted, requires region-specific cofactors in the form of Hox proteins to co-activate subclass-specific effector genes in post-mitotic motor neurons. This intersectional gene regulatory principle for neuronal subclass diversification may be conserved from nematodes to mice. © 2017, eLife Sciences Publications Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)e25751
JournaleLife
Volume6
Issue number3
DOIs
Publication statusPublished - 2017

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Kratsios, P., Kerk, SY., Catela, C., Liang, J., Vidal, B., Bayer, EA., Feng, W., De La Cruz, ED., Croci, L., Consalez, GG., Mizumoto, K., & Hobert, O. (2017). An intersectional gene regulatory strategy defines subclass diversity of C. Elegans motor neurons. eLife, 6(3), e25751. https://doi.org/10.7554/eLife.25751