An intrauterine progesterone contraceptive system (52 mg) used in pre- and peri-menopausal patients with endometrial hyperplasia

A. Volpe, A. Botticelli, M. Abrate, E. Dalla Vecchia, M. Mantovani, C. Carani, A. Grasso, V. Mazza, G. C. Di Renzo

Research output: Contribution to journalArticle

Abstract

An intrauterine progesterone contraceptive system (IPCS) (52 mg) was inserted in 25 women with cystic endometrial hyperplasia. Among these women, 11 complained of heavy climacteric symptoms and also received an oestrogen replacement therapy consisting of conjugated oestrogens (0.625 mg/day) administered cyclically for 3 out of 4 wk. Prior to the therapy and after 6 mth of treatment, follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), oestrone (E1) and oestradiol (E2) plasma levels were measured and endometrial histology was evaluated. In the women receiving IPCS treatment alone, there were no significant changes in FSH, LH, PRL, E1 and E2 plasma levels. However, there were remarkable changes found in their endometrial histology. In the remaining women receiving both treatments, there was a sharp decrease in FSH and LH plasma levels and an increase in E1 and E2 plasma levels, while the prolactin levels remained unchanged. With the exception of two of these women, the endometrial histology changed remarkably. The endometrial morphology of the two exceptions remained unchanged. All climacteric symptoms disappeared after the administration of both IPCS and the oestrogen replacement therapy. The remarkable changes which did occur in the endometrial histology resulted in a less active glandular epithelium and stromal decidual formation, thus proving a useful effect of treatment.

Original languageEnglish
Pages (from-to)73-79
Number of pages7
JournalMaturitas
Volume4
Issue number1
DOIs
Publication statusPublished - 1982

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Keywords

  • Endometrium
  • Hyperplasia
  • IUD
  • Progesterone

ASJC Scopus subject areas

  • Ageing
  • Obstetrics and Gynaecology

Cite this

Volpe, A., Botticelli, A., Abrate, M., Dalla Vecchia, E., Mantovani, M., Carani, C., Grasso, A., Mazza, V., & Di Renzo, G. C. (1982). An intrauterine progesterone contraceptive system (52 mg) used in pre- and peri-menopausal patients with endometrial hyperplasia. Maturitas, 4(1), 73-79. https://doi.org/10.1016/0378-5122(82)90022-6