An investigation of hearing impairment in de-novo Parkinson's disease patients: A preliminary study

Valerio Pisani, Renata Sisto, Arturo Moleti, Roberta Di Mauro, Antonio Pisani, Livia Brusa, Maria Concetta Altavista, Paolo Stanzione, Stefano Di Girolamo

Research output: Contribution to journalArticle

Abstract

Objective: To investigate the peripheral auditory pathway in Parkinson's disease (PD) by using objective, quantitative and non-invasive audiological techniques, transient-evoked (TEOAE) and distortion product (DPOAE) otoacoustic emissions, in order to detect subclinical alterations of cochlear functioning and possible changes after dopaminergic stimulation. Methods: We enrolled 11 untreated de-novo PD patients and 11 age and sex-matched healthy controls. Subjects underwent a routine audiological evaluation and otoacoustic emission recordings. The patients were then slowly-titrated to a stable dose of 100mg levodopa four times in a day. A post-treatment assessment was made in order to detect significant changes in audiological responses. Finally, possible associations between clinical data and hearing results were also evaluated. Results: At pure-tone audiometry, higher auditory threshold levels were observed in PD when compared to the controls. Moreover, DPOAE responses in PD patients were found low at almost all tested frequencies, suggesting subclinical cochlear damage. Interestingly, after dopaminergic treatment, a significant increase in DPOAE responses was detected. Notably, DPOAE dysfunction correlated with clinical severity, whereas high hearing thresholds appeared positively related with more prolonged disease duration. Conclusions: Our findings demonstrate that otoacoustic emission recording and pure-tone audiometry reveal levodopa-sensitive cochlear dysfunction and hearing loss in PD. A parallel improvement in subjective motor symptoms and DPOAE objective responses could help clinicians in monitoring therapeutic responses and dynamic changes during the course of the disease.

Original languageEnglish
Pages (from-to)987-991
Number of pages5
JournalParkinsonism and Related Disorders
Volume21
Issue number8
DOIs
Publication statusPublished - Aug 1 2015

Fingerprint

Hearing Loss
Parkinson Disease
Pure-Tone Audiometry
Cochlea
Levodopa
Hearing
Auditory Threshold
Auditory Pathways
Sensorineural Hearing Loss
Therapeutics

Keywords

  • Cochlea
  • Hearing
  • Levodopa
  • Otoacoustic emission
  • Parkinson's disease

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neurology

Cite this

An investigation of hearing impairment in de-novo Parkinson's disease patients : A preliminary study. / Pisani, Valerio; Sisto, Renata; Moleti, Arturo; Di Mauro, Roberta; Pisani, Antonio; Brusa, Livia; Altavista, Maria Concetta; Stanzione, Paolo; Di Girolamo, Stefano.

In: Parkinsonism and Related Disorders, Vol. 21, No. 8, 01.08.2015, p. 987-991.

Research output: Contribution to journalArticle

Pisani, Valerio ; Sisto, Renata ; Moleti, Arturo ; Di Mauro, Roberta ; Pisani, Antonio ; Brusa, Livia ; Altavista, Maria Concetta ; Stanzione, Paolo ; Di Girolamo, Stefano. / An investigation of hearing impairment in de-novo Parkinson's disease patients : A preliminary study. In: Parkinsonism and Related Disorders. 2015 ; Vol. 21, No. 8. pp. 987-991.
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