An investigation of the influence of patient-related factors and comedications on lamotrigine clearance in patients with epilepsy

André Oliveira Baldoni, Priscila Freitas-Lima, Flávia Isaura de Santi Ferreira, Edson Zangiacomi Martinez, Regina Helena Costa Queiroz, Americo Ceiki Sakamoto, Veriano Alexandre, Emilio Perucca, Leonardo Regis Leira Pereira

Research output: Contribution to journalArticle

Abstract

Lamotrigine (LTG) is one of the most widely used antiepileptic drugs. Confusion still exists in the literature as to the relative influence of age, body weight, and concomitant drug therapy on LTG pharmacokinetics. So, the objective of this study is to evaluate the influence of patient-related factors and comedication on LTG apparent oral clearance (CL/F). A therapeutic drug-monitoring database was used to identify steady-state plasma LTG concentrations in 210 patients. LTG CL/F values were calculated for each patient according to the equation CL/F (L/h per kg) = LTG daily dose (mg/kg)/Css (steady state concentration) (mg/L) × 24 h. A linear-regression model was used to assess the influence of gender, dose, age, and body weight in LTG CL/F. The influence of comedication on LTG CL/F was investigated by applying the Bonferroni post-test. The lowest LTG CL/F was found in patients comedicated with valproate (VPA) (mean, 0.0183 L/h per kg), followed by patients receiving VPA + enzyme inducers (0.0271 L/h per kg), patients on LTG monotherapy (0.0298 L/h per kg) and patients comedicated with enzyme inducers (0.056 L/h per kg) LTG CL/F correlated significantly with LTG dose (P 

Original languageEnglish
Pages (from-to)685-689
Number of pages5
JournalClinical and Experimental Pharmacology and Physiology
Volume43
Issue number7
DOIs
Publication statusPublished - Jul 1 2016

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Pharmacology

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  • Cite this

    Baldoni, A. O., Freitas-Lima, P., de Santi Ferreira, F. I., Martinez, E. Z., Queiroz, R. H. C., Sakamoto, A. C., Alexandre, V., Perucca, E., & Pereira, L. R. L. (2016). An investigation of the influence of patient-related factors and comedications on lamotrigine clearance in patients with epilepsy. Clinical and Experimental Pharmacology and Physiology, 43(7), 685-689. https://doi.org/10.1111/1440-1681.12584