BACKGROUND: the APICE study evaluates the cost-effectiveness of nanoparticle albumin-bound paclitaxel (nab-paclitaxel - Nab-P) + gemcitabine (G) vs G alone in metastatic pancreatic cancer (MPC) from the Italian National Health Service (INHS) standpoint.
RESEARCH DESIGN AND METHODS: A 4-year, 4 health states (progression-free; progressed; end of life; death) Markov model based on the MPACT trial was developed to estimate costs (Euro [€], 2017 values), and quality-adjusted life years (QALYs). Patients were assumed to receive intravenously Nab-P 125 mg/m2 + G 1000 mg/m2 on days 1, 8, and 15 every 4 weeks or G alone 1000 mg/m2 weekly for 7 out of 8 weeks (cycle 1) and then on days 1, 8, and 15 every 4 weeks (cycle 2 and subsequent cycles) until progression. One-way and probabilistic sensitivity analyses explored the uncertainty surrounding the baseline incremental cost-utility ratio (ICUR).
RESULTS: Nab-P + G totals 0.154 incremental QALYs and €7082.68 incremental costs vs G alone. ICUR (€46,021.58) is lower than the informal threshold value of €87,330 adopted by the Italian Medicines Agency during 2010-2013 for reimbursing oncological drugs. Sensitivity analyses confirmed the robustness of the baseline findings.
CONCLUSIONS: Nab-P + G in MPC patients can be considered cost-effective for the INHS.
|Number of pages||12|
|Journal||Expert Review of Pharmacoeconomics and Outcomes Research|
|Publication status||Published - Aug 2018|
- Albumins/administration & dosage
- Antineoplastic Combined Chemotherapy Protocols/administration & dosage
- Cost-Benefit Analysis
- Deoxycytidine/administration & dosage
- Disease-Free Survival
- Markov Chains
- Neoplasm Metastasis
- Paclitaxel/administration & dosage
- Pancreatic Neoplasms/drug therapy
- Quality-Adjusted Life Years