An italian experience of high-dose chemotherapy and autologous bone marrow transplantation (ABMT) in germ cell tumours. Suggestions for future direction

Giovanni Rosti, Livia Albertazzi, Amelia Tienghi, Giammaria Fiorentini, Daniele Turci, Giorgio Cruciani, Manuela Flamini, Marzia Argnani, Maria Antonietta Bassetto, Roberto Salvioni, Maurizio Marangolo

Research output: Contribution to journalArticlepeer-review

Abstract

In this paper an Italian cooperative trial investigates the role of a high-dose regimen with carboplatin, etoposide and ifosfamide in germ cell tumours. Twenty-eight patients underwent one or two transplants. Seventeen with progressive disease. Nine in sensitive relapse and two with stable disease after salvage therapy. Toxicity was generally moderate: two deaths occurred at day 15 from ABMT (one from VOD and one from tumour growth). Five patients are alive and disease free at least 10 months follow-up. In highly pre-treated patients this high-dose combination seems to give an option of cure for relapsed patients. Early transplantation is suggested.

Original languageEnglish
Pages (from-to)59-63
Number of pages5
JournalLeukemia and Lymphoma
Volume7
Issue numberS1
DOIs
Publication statusPublished - 1992

Keywords

  • Bone marrow transplantation
  • Germ cell
  • High-dose chemotherapy
  • Tumours

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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