An Italian Prospective Experience on the Association Between Congenital Cytomegalovirus Infection and Autistic Spectrum Disorder

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The aim of this retrospective study, with prospective data collection, was to correlate congenital cytomegalovirus (CMV) infection with autism spectrum disorder (ASD) and to define its prevalence. Seventy proven congenitally-infected infants, born between 2007 and 2012, were referred to our centre for CMV diagnosis and follow-up, which consisted of a consolidated protocol allowing an early evaluation of autism. We considered four children 2-year old, two of whom, at the age of 3, were diagnosed with ASD demonstrating a 2-3 fold higher prevalence (2.86%), than that in general Italian population (0.66-1.36%).Our protocol enabled us to make the earliest diagnosis and highlight the role of the virus among other causes of autism, which may be a long term sequela of congenital CMV.

Original languageEnglish
Pages (from-to)1490-1495
Number of pages6
JournalJournal of Autism and Developmental Disorders
Volume47
Issue number5
DOIs
Publication statusPublished - May 2017

Fingerprint

Cytomegalovirus Infections
Autistic Disorder
Cytomegalovirus
Early Diagnosis
Retrospective Studies
Viruses
Population
Autism Spectrum Disorder

Keywords

  • Autism Spectrum Disorder
  • Child, Preschool
  • Cytomegalovirus Infections
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Italy
  • Male
  • Prevalence
  • Prospective Studies
  • Retrospective Studies
  • Journal Article

Cite this

@article{f22595ae7e78460f90a062661bf7f281,
title = "An Italian Prospective Experience on the Association Between Congenital Cytomegalovirus Infection and Autistic Spectrum Disorder",
abstract = "The aim of this retrospective study, with prospective data collection, was to correlate congenital cytomegalovirus (CMV) infection with autism spectrum disorder (ASD) and to define its prevalence. Seventy proven congenitally-infected infants, born between 2007 and 2012, were referred to our centre for CMV diagnosis and follow-up, which consisted of a consolidated protocol allowing an early evaluation of autism. We considered four children 2-year old, two of whom, at the age of 3, were diagnosed with ASD demonstrating a 2-3 fold higher prevalence (2.86{\%}), than that in general Italian population (0.66-1.36{\%}).Our protocol enabled us to make the earliest diagnosis and highlight the role of the virus among other causes of autism, which may be a long term sequela of congenital CMV.",
keywords = "Autism Spectrum Disorder, Child, Preschool, Cytomegalovirus Infections, Female, Humans, Infant, Infant, Newborn, Italy, Male, Prevalence, Prospective Studies, Retrospective Studies, Journal Article",
author = "Francesca Garofoli and Giuseppina Lombardi and Simona Orcesi and Camilla Pisoni and Iolanda Mazzucchelli and Micol Angelini and Umberto Balottin and Mauro Stronati",
year = "2017",
month = "5",
doi = "10.1007/s10803-017-3050-3",
language = "English",
volume = "47",
pages = "1490--1495",
journal = "Journal of Autism and Developmental Disorders",
issn = "0162-3257",
publisher = "Springer New York",
number = "5",

}

TY - JOUR

T1 - An Italian Prospective Experience on the Association Between Congenital Cytomegalovirus Infection and Autistic Spectrum Disorder

AU - Garofoli, Francesca

AU - Lombardi, Giuseppina

AU - Orcesi, Simona

AU - Pisoni, Camilla

AU - Mazzucchelli, Iolanda

AU - Angelini, Micol

AU - Balottin, Umberto

AU - Stronati, Mauro

PY - 2017/5

Y1 - 2017/5

N2 - The aim of this retrospective study, with prospective data collection, was to correlate congenital cytomegalovirus (CMV) infection with autism spectrum disorder (ASD) and to define its prevalence. Seventy proven congenitally-infected infants, born between 2007 and 2012, were referred to our centre for CMV diagnosis and follow-up, which consisted of a consolidated protocol allowing an early evaluation of autism. We considered four children 2-year old, two of whom, at the age of 3, were diagnosed with ASD demonstrating a 2-3 fold higher prevalence (2.86%), than that in general Italian population (0.66-1.36%).Our protocol enabled us to make the earliest diagnosis and highlight the role of the virus among other causes of autism, which may be a long term sequela of congenital CMV.

AB - The aim of this retrospective study, with prospective data collection, was to correlate congenital cytomegalovirus (CMV) infection with autism spectrum disorder (ASD) and to define its prevalence. Seventy proven congenitally-infected infants, born between 2007 and 2012, were referred to our centre for CMV diagnosis and follow-up, which consisted of a consolidated protocol allowing an early evaluation of autism. We considered four children 2-year old, two of whom, at the age of 3, were diagnosed with ASD demonstrating a 2-3 fold higher prevalence (2.86%), than that in general Italian population (0.66-1.36%).Our protocol enabled us to make the earliest diagnosis and highlight the role of the virus among other causes of autism, which may be a long term sequela of congenital CMV.

KW - Autism Spectrum Disorder

KW - Child, Preschool

KW - Cytomegalovirus Infections

KW - Female

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Italy

KW - Male

KW - Prevalence

KW - Prospective Studies

KW - Retrospective Studies

KW - Journal Article

U2 - 10.1007/s10803-017-3050-3

DO - 10.1007/s10803-017-3050-3

M3 - Article

C2 - 28258350

VL - 47

SP - 1490

EP - 1495

JO - Journal of Autism and Developmental Disorders

JF - Journal of Autism and Developmental Disorders

SN - 0162-3257

IS - 5

ER -