An Italian Prospective Experience on the Association Between Congenital Cytomegalovirus Infection and Autistic Spectrum Disorder

Francesca Garofoli, Giuseppina Lombardi, Simona Orcesi, Camilla Pisoni, Iolanda Mazzucchelli, Micol Angelini, Umberto Balottin, Mauro Stronati

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this retrospective study, with prospective data collection, was to correlate congenital cytomegalovirus (CMV) infection with autism spectrum disorder (ASD) and to define its prevalence. Seventy proven congenitally-infected infants, born between 2007 and 2012, were referred to our centre for CMV diagnosis and follow-up, which consisted of a consolidated protocol allowing an early evaluation of autism. We considered four children 2-year old, two of whom, at the age of 3, were diagnosed with ASD demonstrating a 2-3 fold higher prevalence (2.86%), than that in general Italian population (0.66-1.36%).Our protocol enabled us to make the earliest diagnosis and highlight the role of the virus among other causes of autism, which may be a long term sequela of congenital CMV.

Original languageEnglish
Pages (from-to)1490-1495
Number of pages6
JournalJournal of Autism and Developmental Disorders
Volume47
Issue number5
DOIs
Publication statusPublished - May 2017

Keywords

  • Autism Spectrum Disorder
  • Child, Preschool
  • Cytomegalovirus Infections
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Italy
  • Male
  • Prevalence
  • Prospective Studies
  • Retrospective Studies
  • Journal Article

Fingerprint Dive into the research topics of 'An Italian Prospective Experience on the Association Between Congenital Cytomegalovirus Infection and Autistic Spectrum Disorder'. Together they form a unique fingerprint.

Cite this