An MRI study of Chlamydia pneumoniae infection in Italian multiple sclerosis patients

Luigi M E Grimaldi, A. Pincherle, F. Martinelli-Boneschi, M. Filippi, F. Patti, A. Reggio, D. Franciotta, L. Allegra, G. Comi, F. Blasi

Research output: Contribution to journalArticle

Abstract

We amplified sequences of the Chlamydia pneumoniae (CP) major-outer membrane protein in the cerebrospinal fluid (CSF) from 23 of 107 (21.5%) relapsing-remitting or secondary progressive multiple sclerosis (MS) patients and two of 77 (2.6%) patients with other neurological diseases (OND) (P = 0.00022). CP+ patients showed magnetic resonance imaging (MRI) evidence of more active disease (P = 0.02) compared to CP- MS patients and tended to have an anticipation of age at disease onset (32.3±12 versus 28.5±10 years; P = ns) causing a longer disease duration (7.5±5 versus 4.4±4 years; P = 0.016) at the time of clinical evaluation. These findings, although indirectly, suggest that CP infection of the central nervous system (CNS) might affect disease course in a subgroup of MS patients.

Original languageEnglish
Pages (from-to)467-471
Number of pages5
JournalMultiple Sclerosis Journal
Volume9
Issue number5
DOIs
Publication statusPublished - Oct 2003

Keywords

  • Cerebrospinal fluid
  • Chlamydia pneumoniae
  • MRI
  • Multiple sclerosis
  • PCR

ASJC Scopus subject areas

  • Clinical Neurology

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