An observational study comparing continuous subcutaneous insulin infusion (CSII) and insulin glargine in children with type 1 diabetes

Riccardo Schiaffini, Paolo Ciampalini, Sabrina Spera, Marco Cappa, Antonino Crinó

Research output: Contribution to journalArticle

Abstract

Objective: The advantages of continuous subcutaneous insulin infusion (CSII) or insulin glargine have been demonstrated both in adult and paediatric diabetic patients; however, as no data comparing these two approaches during childhood are available, we have examined the efficacy of these two intensive approaches. Research design and methods: We retrospectively evaluated data from 36 diabetic children, who had changed their previous insulin regimen [with isophane insulin (NPH) at bedtime] because of HbA 1c levels >8.0%. Twenty patients underwent CSII, while the other 16 (significantly younger for age) started insulin glargine at bedtime. Results: At 6 and 12 months, CSII-treated patients showed a significant reduction in HbA 1c values from 8.5 ± 1.8 to 7.4 ± 1.1% and to 7.6 ± 1.2%, respectively. The insulin requirement significantly decreased from 0.93 ± 0.2 IU/kg to 0.73 ± 0.2 IU/kg of body weight and to 0.74 ± 0.15 IU/kg of body weight, respectively, while no significant differences were observed for BMI SDS, fructosamine and severe hypoglycaemic events. The patients treated with glargine showed a small decline in HbA 1c values from 8.9 ± 1.7 to 8.3 ± 0.9% (not significant) in the first 6 months of treatment and to 8.2 ± 0.9% after 12 months. Conclusion: The basal insulin supplementation can be supplied effectively in children with type 1 diabetes by either CSII or insulin glargine. As previously reported for adults, it is confirmed that CSII is the best current intensive approach aimed to the improvement of glycaemic control.

Original languageEnglish
Pages (from-to)347-352
Number of pages6
JournalDiabetes/Metabolism Research and Reviews
Volume21
Issue number4
DOIs
Publication statusPublished - Jul 2005

Keywords

  • Basal insulin supplementation
  • CSII
  • Insulin Glargine
  • Type 1 diabetes

ASJC Scopus subject areas

  • Endocrinology
  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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