An observational study of sequential protein-sparing, very low-calorie ketogenic diet (Oloproteic diet) and hypocaloric Mediterranean-like diet for the treatment of obesity

Giuseppe Castaldo, Luigi Monaco, Laura Castaldo, Giovanna Galdo, Emanuele Cereda

Research output: Contribution to journalArticle


The impact of a rehabilitative multi-step dietary program consisting in different diets has been scantily investigated. In an open-label study, 73 obese patients underwent a two-phase weight loss (WL) program: a 3-week protein-sparing, very low-calorie, ketogenic diet (® Diet) and a 6-week hypocaloric (25–30 kcal/kg of ideal body weight/day), low glycemic index, Mediterranean-like diet (hypo-MD). Both phases improved visceral adiposity, liver enzymes, GH levels, blood pressure and glucose and lipid metabolism. However, the hypo-MD was responsible for a re-increase in blood lipids and glucose tolerance parameters. Changes in visceral adiposity and glucose control-related variables were more consistent in patients with metabolic syndrome. However, in these patients the hypo-MD did not result in a consistent re-increase in glucose control-related variables. A dietary program consisting in a ketogenic regimen followed by a balanced MD appeared to be feasible and efficacious in reducing cardiovascular risk, particularly in patients with metabolic syndrome.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalInternational Journal of Food Sciences and Nutrition
Publication statusAccepted/In press - May 19 2016



  • Ketogenic diet
  • Mediterranean diet
  • obesity
  • weight loss

ASJC Scopus subject areas

  • Food Science

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