An oncologist-based model of cancer genetic counselling for hereditary breast and ovarian cancer

A. Contegiacomo, M. Pensabene, I. Capuano, L. Tauchmanova, M. Federico, D. Turchetti, L. Cortesi, P. Marcheti, E. Ricevuto, G. Cianci, S. Venuta, V. Barbieri, V. Silingardi

Research output: Contribution to journalArticlepeer-review


Background: We describe a multistep model of cancer genetic counselling designed to promote awareness, and disease surveillance and preventive measures for hereditary and familial brest and ovarian cancer. Patients and methods: Step T0 of the model entails information giving; this is followed by pedigree analysis and risk estimation (T1), risk communication and genetic testing (T2), and genetic test result communication (T3). User consent was required to proceed from one step to the next. Surveillance and preventive measures are proposed to at-risk users. Of the 311 subjects who requested cancer genetic counselling, consent data to each counselling step were available for 295:93 were disease-free, 187 had breast cancer, 12 had ovarian cancer and three had breast plus ovarian cancer. Results: Consent was high at T0 (98.39%), T1 (96.40%) and T2 (99.65%). Consent decreased at the crucial points of counselling: T2 (87.71%) and T3 [genetic test result communication (85.08%), and extension of counselling to and testing of relatives (65.36%)]. Conclusions: The model fosters the user's knowledge about cancer and favours identification of at-risk subjects. Furthermore, by promoting awareness about genetic testing and surveillance measures, the algorithm enables users to make a fully informed choice of action, in case of predisposing or familial cancer risk.

Original languageEnglish
Pages (from-to)726-732
Number of pages7
JournalAnnals of Oncology
Issue number5
Publication statusPublished - May 2004


  • Breast cancer
  • Genetic counselling
  • Ovarian cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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