An open-label pilot study of the use of rivastigmine to promote functional recovery in patients with unilateral spatial neglect due to first ischemic stroke

Stefano Paolucci, Ivana Bureca, Mirella Multari, Ugo Nocentini, Alessandro Matano

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to evaluate the efficacy and safety of rivastigmine as add-on treatment to specific cognitive rehabilitation for unilateral spatial neglect (USN). Twenty patients were randomly assigned either to rehabilitation treatment only (No-RIV) or to rivastigmine (3 mg twice a day, for 8 weeks) add-on treatment (RIV+,). USN and functional status were evaluated by means of specific and validated instruments at baseline, at discharge and at one-month follow up. Compared with the untreated patients, the RIV+ subjects, at discharge, recorded significantly better discharge scores and higher effectiveness on two of the scales. However, subsequent further improvement of the No-RIV patients meant that at follow up there was no significant difference between the two groups. No other statistically significant difference was found. Rivastigmine as add-on treatment to specific cognitive training for USN may improve and accelerate recovery on some specific impairment tests as compared with cognitive training alone.

Original languageEnglish
Pages (from-to)195-200
Number of pages6
JournalFunctional Neurology
Volume25
Issue number4
Publication statusPublished - Oct 2010

Keywords

  • Neglect
  • Rehabilitation
  • Rivastigmine
  • Stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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