An organic khorasan wheat-based replacement diet improves risk profile of patients with acute coronary syndrome: A randomized crossover trial

Anne Whittaker, Francesco Sofi, Maria Luisa Eliana Luisi, Elena Rafanelli, Claudia Fiorillo, Matteo Becatti, Rosanna Abbate, Alessandro Casini, Gian Franco Gensini, Stefano Benedettelli

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Khorasan wheat is an ancient grain with previously reported health benefits in clinically healthy subjects. The aim of this study was to examine whether a replacement diet, thereby substituting all other cereal grains, with products made with organic khorasan wheat could provide additive protective effects in reducing lipid, oxidative and inflammatory risk factors, in patients with Acute Coronary Syndromes (ACS) in comparison to a similar replacement diet using products made from organic modern wheat. A randomized double-blinded crossover trial with two intervention phases was conducted on 22 ACS patients (9 F; 13 M). The patients were assigned to consume products (bread, pasta, biscuits and crackers) made either from organic semi-whole khorasan wheat or organic semi-whole control wheat for eight weeks in a random order. On average, patients ingested 62.0 g dry weight (DW) day−1 khorasan or control semolina; and 140.5 g DW day−1 khorasan or control flour, respectively. An eight-week washout period was implemented between the respective interventions. Blood analyses were performed both at the beginning and end of each intervention phase; thereby permitting a comparison of both the khorasan and control intervention phases, respectively, on circulatory risk factors for the same patient. Consumption of products made with khorasan wheat resulted in a significant amelioration in total cholesterol (−6.8%), low-density lipoprotein cholesterol (LDL-C) (−8.1%) glucose (−8%) and insulin (−24.6%) from baseline levels, independently of age, sex, traditional risk factors, medication and diet quality. Moreover, there was a significant reduction in reactive oxygen species (ROS), lipoperoxidation of circulating monocytes and lymphocytes, as well as in the levels of Tumor Necrosis Factor-alpha. No significant differences from baseline in the same patients were observed after the conventional control wheat intervention phase. The present results suggest that a replacement diet with cereal products made from organic khorasan wheat provides additional protection in patients with ACS. Circulating cardiovascular risk factors, including lipid parameters, and markers of both oxidative stress and inflammatory status, were reduced, irrespective of the number and combination of medicinal therapies with proven efficacy in secondary prevention.

Original languageEnglish
Pages (from-to)3401-3415
Number of pages15
JournalNutrients
Volume7
Issue number5
DOIs
Publication statusPublished - May 11 2015

Fingerprint

risk profile
Acute Coronary Syndrome
Cross-Over Studies
Triticum
Diet
wheat
diet
risk factors
crackers
Lipids
Weights and Measures
semolina
biscuits
grain products
cross-over studies
pasta
Bread
nutritional adequacy
Flour
Insurance Benefits

Keywords

  • Acute coronary syndrome
  • Conventional wheat
  • Diet
  • Khorasan wheat
  • Secondary prevention

ASJC Scopus subject areas

  • Food Science

Cite this

An organic khorasan wheat-based replacement diet improves risk profile of patients with acute coronary syndrome : A randomized crossover trial. / Whittaker, Anne; Sofi, Francesco; Luisi, Maria Luisa Eliana; Rafanelli, Elena; Fiorillo, Claudia; Becatti, Matteo; Abbate, Rosanna; Casini, Alessandro; Gensini, Gian Franco; Benedettelli, Stefano.

In: Nutrients, Vol. 7, No. 5, 11.05.2015, p. 3401-3415.

Research output: Contribution to journalArticle

Whittaker, A, Sofi, F, Luisi, MLE, Rafanelli, E, Fiorillo, C, Becatti, M, Abbate, R, Casini, A, Gensini, GF & Benedettelli, S 2015, 'An organic khorasan wheat-based replacement diet improves risk profile of patients with acute coronary syndrome: A randomized crossover trial', Nutrients, vol. 7, no. 5, pp. 3401-3415. https://doi.org/10.3390/nu7053401
Whittaker, Anne ; Sofi, Francesco ; Luisi, Maria Luisa Eliana ; Rafanelli, Elena ; Fiorillo, Claudia ; Becatti, Matteo ; Abbate, Rosanna ; Casini, Alessandro ; Gensini, Gian Franco ; Benedettelli, Stefano. / An organic khorasan wheat-based replacement diet improves risk profile of patients with acute coronary syndrome : A randomized crossover trial. In: Nutrients. 2015 ; Vol. 7, No. 5. pp. 3401-3415.
@article{8f19f651d7f44cfb912015183ef57db9,
title = "An organic khorasan wheat-based replacement diet improves risk profile of patients with acute coronary syndrome: A randomized crossover trial",
abstract = "Khorasan wheat is an ancient grain with previously reported health benefits in clinically healthy subjects. The aim of this study was to examine whether a replacement diet, thereby substituting all other cereal grains, with products made with organic khorasan wheat could provide additive protective effects in reducing lipid, oxidative and inflammatory risk factors, in patients with Acute Coronary Syndromes (ACS) in comparison to a similar replacement diet using products made from organic modern wheat. A randomized double-blinded crossover trial with two intervention phases was conducted on 22 ACS patients (9 F; 13 M). The patients were assigned to consume products (bread, pasta, biscuits and crackers) made either from organic semi-whole khorasan wheat or organic semi-whole control wheat for eight weeks in a random order. On average, patients ingested 62.0 g dry weight (DW) day−1 khorasan or control semolina; and 140.5 g DW day−1 khorasan or control flour, respectively. An eight-week washout period was implemented between the respective interventions. Blood analyses were performed both at the beginning and end of each intervention phase; thereby permitting a comparison of both the khorasan and control intervention phases, respectively, on circulatory risk factors for the same patient. Consumption of products made with khorasan wheat resulted in a significant amelioration in total cholesterol (−6.8{\%}), low-density lipoprotein cholesterol (LDL-C) (−8.1{\%}) glucose (−8{\%}) and insulin (−24.6{\%}) from baseline levels, independently of age, sex, traditional risk factors, medication and diet quality. Moreover, there was a significant reduction in reactive oxygen species (ROS), lipoperoxidation of circulating monocytes and lymphocytes, as well as in the levels of Tumor Necrosis Factor-alpha. No significant differences from baseline in the same patients were observed after the conventional control wheat intervention phase. The present results suggest that a replacement diet with cereal products made from organic khorasan wheat provides additional protection in patients with ACS. Circulating cardiovascular risk factors, including lipid parameters, and markers of both oxidative stress and inflammatory status, were reduced, irrespective of the number and combination of medicinal therapies with proven efficacy in secondary prevention.",
keywords = "Acute coronary syndrome, Conventional wheat, Diet, Khorasan wheat, Secondary prevention",
author = "Anne Whittaker and Francesco Sofi and Luisi, {Maria Luisa Eliana} and Elena Rafanelli and Claudia Fiorillo and Matteo Becatti and Rosanna Abbate and Alessandro Casini and Gensini, {Gian Franco} and Stefano Benedettelli",
year = "2015",
month = "5",
day = "11",
doi = "10.3390/nu7053401",
language = "English",
volume = "7",
pages = "3401--3415",
journal = "Nutrients",
issn = "2072-6643",
publisher = "NLM (Medline)",
number = "5",

}

TY - JOUR

T1 - An organic khorasan wheat-based replacement diet improves risk profile of patients with acute coronary syndrome

T2 - A randomized crossover trial

AU - Whittaker, Anne

AU - Sofi, Francesco

AU - Luisi, Maria Luisa Eliana

AU - Rafanelli, Elena

AU - Fiorillo, Claudia

AU - Becatti, Matteo

AU - Abbate, Rosanna

AU - Casini, Alessandro

AU - Gensini, Gian Franco

AU - Benedettelli, Stefano

PY - 2015/5/11

Y1 - 2015/5/11

N2 - Khorasan wheat is an ancient grain with previously reported health benefits in clinically healthy subjects. The aim of this study was to examine whether a replacement diet, thereby substituting all other cereal grains, with products made with organic khorasan wheat could provide additive protective effects in reducing lipid, oxidative and inflammatory risk factors, in patients with Acute Coronary Syndromes (ACS) in comparison to a similar replacement diet using products made from organic modern wheat. A randomized double-blinded crossover trial with two intervention phases was conducted on 22 ACS patients (9 F; 13 M). The patients were assigned to consume products (bread, pasta, biscuits and crackers) made either from organic semi-whole khorasan wheat or organic semi-whole control wheat for eight weeks in a random order. On average, patients ingested 62.0 g dry weight (DW) day−1 khorasan or control semolina; and 140.5 g DW day−1 khorasan or control flour, respectively. An eight-week washout period was implemented between the respective interventions. Blood analyses were performed both at the beginning and end of each intervention phase; thereby permitting a comparison of both the khorasan and control intervention phases, respectively, on circulatory risk factors for the same patient. Consumption of products made with khorasan wheat resulted in a significant amelioration in total cholesterol (−6.8%), low-density lipoprotein cholesterol (LDL-C) (−8.1%) glucose (−8%) and insulin (−24.6%) from baseline levels, independently of age, sex, traditional risk factors, medication and diet quality. Moreover, there was a significant reduction in reactive oxygen species (ROS), lipoperoxidation of circulating monocytes and lymphocytes, as well as in the levels of Tumor Necrosis Factor-alpha. No significant differences from baseline in the same patients were observed after the conventional control wheat intervention phase. The present results suggest that a replacement diet with cereal products made from organic khorasan wheat provides additional protection in patients with ACS. Circulating cardiovascular risk factors, including lipid parameters, and markers of both oxidative stress and inflammatory status, were reduced, irrespective of the number and combination of medicinal therapies with proven efficacy in secondary prevention.

AB - Khorasan wheat is an ancient grain with previously reported health benefits in clinically healthy subjects. The aim of this study was to examine whether a replacement diet, thereby substituting all other cereal grains, with products made with organic khorasan wheat could provide additive protective effects in reducing lipid, oxidative and inflammatory risk factors, in patients with Acute Coronary Syndromes (ACS) in comparison to a similar replacement diet using products made from organic modern wheat. A randomized double-blinded crossover trial with two intervention phases was conducted on 22 ACS patients (9 F; 13 M). The patients were assigned to consume products (bread, pasta, biscuits and crackers) made either from organic semi-whole khorasan wheat or organic semi-whole control wheat for eight weeks in a random order. On average, patients ingested 62.0 g dry weight (DW) day−1 khorasan or control semolina; and 140.5 g DW day−1 khorasan or control flour, respectively. An eight-week washout period was implemented between the respective interventions. Blood analyses were performed both at the beginning and end of each intervention phase; thereby permitting a comparison of both the khorasan and control intervention phases, respectively, on circulatory risk factors for the same patient. Consumption of products made with khorasan wheat resulted in a significant amelioration in total cholesterol (−6.8%), low-density lipoprotein cholesterol (LDL-C) (−8.1%) glucose (−8%) and insulin (−24.6%) from baseline levels, independently of age, sex, traditional risk factors, medication and diet quality. Moreover, there was a significant reduction in reactive oxygen species (ROS), lipoperoxidation of circulating monocytes and lymphocytes, as well as in the levels of Tumor Necrosis Factor-alpha. No significant differences from baseline in the same patients were observed after the conventional control wheat intervention phase. The present results suggest that a replacement diet with cereal products made from organic khorasan wheat provides additional protection in patients with ACS. Circulating cardiovascular risk factors, including lipid parameters, and markers of both oxidative stress and inflammatory status, were reduced, irrespective of the number and combination of medicinal therapies with proven efficacy in secondary prevention.

KW - Acute coronary syndrome

KW - Conventional wheat

KW - Diet

KW - Khorasan wheat

KW - Secondary prevention

UR - http://www.scopus.com/inward/record.url?scp=84929378549&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929378549&partnerID=8YFLogxK

U2 - 10.3390/nu7053401

DO - 10.3390/nu7053401

M3 - Article

AN - SCOPUS:84929378549

VL - 7

SP - 3401

EP - 3415

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 5

ER -