Abstract
Chronic lymphocytic leukaemia (CLL) is characterised by accumulation of CD5+ monoclonal B cells in primary and secondary lymphoid tissues. Genetic defects and stimuli originating from the microenvironment concur to the selection and expansion of the malignant clone. Several lines of evidence, including molecular and functional analysis of the monoclonal immunoglobulin, support the hypothesis that stimulation through the B-cell receptor affects life and death of leukaemic cells. The microenvironment also has a critical role in the survival and accumulation of leukaemic cells within lymphoid organs where signals delivered from the surrounding cells are likely crucial in inducing proliferation. Nevertheless, several major biological issues still remain to be solved including regulation of the balance between proliferation and survival of leukaemic cells and the links between emerging gene abnormalities and microenvironment. In this context, mouse models are helpful tools in understanding disease mechanisms and in evaluating the efficacy of novel therapeutic agents.
| Original language | English |
|---|---|
| Pages (from-to) | 21-32 |
| Number of pages | 12 |
| Journal | Best Practice and Research: Clinical Haematology |
| Volume | 23 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Mar 2010 |
Fingerprint
Keywords
- B-cell receptor
- microenvironment
- mouse models
ASJC Scopus subject areas
- Oncology
- Clinical Biochemistry
Cite this
An overview of chronic lymphocytic leukaemia biology. / Bertilaccio, M. T S; Scielzo, C.; Muzio, M.; Caligaris-Cappio, F.
In: Best Practice and Research: Clinical Haematology, Vol. 23, No. 1, 03.2010, p. 21-32.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - An overview of chronic lymphocytic leukaemia biology
AU - Bertilaccio, M. T S
AU - Scielzo, C.
AU - Muzio, M.
AU - Caligaris-Cappio, F.
PY - 2010/3
Y1 - 2010/3
N2 - Chronic lymphocytic leukaemia (CLL) is characterised by accumulation of CD5+ monoclonal B cells in primary and secondary lymphoid tissues. Genetic defects and stimuli originating from the microenvironment concur to the selection and expansion of the malignant clone. Several lines of evidence, including molecular and functional analysis of the monoclonal immunoglobulin, support the hypothesis that stimulation through the B-cell receptor affects life and death of leukaemic cells. The microenvironment also has a critical role in the survival and accumulation of leukaemic cells within lymphoid organs where signals delivered from the surrounding cells are likely crucial in inducing proliferation. Nevertheless, several major biological issues still remain to be solved including regulation of the balance between proliferation and survival of leukaemic cells and the links between emerging gene abnormalities and microenvironment. In this context, mouse models are helpful tools in understanding disease mechanisms and in evaluating the efficacy of novel therapeutic agents.
AB - Chronic lymphocytic leukaemia (CLL) is characterised by accumulation of CD5+ monoclonal B cells in primary and secondary lymphoid tissues. Genetic defects and stimuli originating from the microenvironment concur to the selection and expansion of the malignant clone. Several lines of evidence, including molecular and functional analysis of the monoclonal immunoglobulin, support the hypothesis that stimulation through the B-cell receptor affects life and death of leukaemic cells. The microenvironment also has a critical role in the survival and accumulation of leukaemic cells within lymphoid organs where signals delivered from the surrounding cells are likely crucial in inducing proliferation. Nevertheless, several major biological issues still remain to be solved including regulation of the balance between proliferation and survival of leukaemic cells and the links between emerging gene abnormalities and microenvironment. In this context, mouse models are helpful tools in understanding disease mechanisms and in evaluating the efficacy of novel therapeutic agents.
KW - B-cell receptor
KW - microenvironment
KW - mouse models
UR - http://www.scopus.com/inward/record.url?scp=77956643987&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956643987&partnerID=8YFLogxK
U2 - 10.1016/j.beha.2009.12.005
DO - 10.1016/j.beha.2009.12.005
M3 - Article
C2 - 20620968
AN - SCOPUS:77956643987
VL - 23
SP - 21
EP - 32
JO - Best Practice and Research in Clinical Haematology
JF - Best Practice and Research in Clinical Haematology
SN - 1521-6926
IS - 1
ER -