Abstract
Delayed pressure urticaria (DPU) is a physical urticaria characterized by the development of deep swellings at sites of pressure application on the skin. Etiopathogenesis of DPU is still unknown, although the available evidence suggests the involvement of mast cells through non-immunologic mechanisms and the role of several mediators beyond histamine, such as proinflammatory cytokines. The management of DPU is complex, also considering that prevention is very difficult and DPU frequently coexists with chronic "idiopathic" urticaria. Moreover, H1-antihistamines, which are the mainstay of treatment for common urticaria, usually provide less satisfactory results as compared with other urticarias. Therefore, numerous treatment alternatives have been proposed for severe refractory cases, such as oral or topical corticosteroids and various drugs with anti-inflammatory effects.
| Original language | English |
|---|---|
| Journal | Dermatologic Therapy |
| Volume | 22 |
| Issue number | SUPPL. 1 |
| DOIs | |
| Publication status | Published - Nov 2009 |
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Keywords
- Delayed pressure urticaria
- Pathogenesis
- Treatment
ASJC Scopus subject areas
- Dermatology
Cite this
An overview of delayed pressure urticaria with special emphasis on pathogenesis and treatment. / Cassano, Nicoletta; Mastrandrea, Valentina; Vestita, Michelangelo; Vena, Gino Antonio.
In: Dermatologic Therapy, Vol. 22, No. SUPPL. 1, 11.2009.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - An overview of delayed pressure urticaria with special emphasis on pathogenesis and treatment
AU - Cassano, Nicoletta
AU - Mastrandrea, Valentina
AU - Vestita, Michelangelo
AU - Vena, Gino Antonio
PY - 2009/11
Y1 - 2009/11
N2 - Delayed pressure urticaria (DPU) is a physical urticaria characterized by the development of deep swellings at sites of pressure application on the skin. Etiopathogenesis of DPU is still unknown, although the available evidence suggests the involvement of mast cells through non-immunologic mechanisms and the role of several mediators beyond histamine, such as proinflammatory cytokines. The management of DPU is complex, also considering that prevention is very difficult and DPU frequently coexists with chronic "idiopathic" urticaria. Moreover, H1-antihistamines, which are the mainstay of treatment for common urticaria, usually provide less satisfactory results as compared with other urticarias. Therefore, numerous treatment alternatives have been proposed for severe refractory cases, such as oral or topical corticosteroids and various drugs with anti-inflammatory effects.
AB - Delayed pressure urticaria (DPU) is a physical urticaria characterized by the development of deep swellings at sites of pressure application on the skin. Etiopathogenesis of DPU is still unknown, although the available evidence suggests the involvement of mast cells through non-immunologic mechanisms and the role of several mediators beyond histamine, such as proinflammatory cytokines. The management of DPU is complex, also considering that prevention is very difficult and DPU frequently coexists with chronic "idiopathic" urticaria. Moreover, H1-antihistamines, which are the mainstay of treatment for common urticaria, usually provide less satisfactory results as compared with other urticarias. Therefore, numerous treatment alternatives have been proposed for severe refractory cases, such as oral or topical corticosteroids and various drugs with anti-inflammatory effects.
KW - Delayed pressure urticaria
KW - Pathogenesis
KW - Treatment
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UR - http://www.scopus.com/inward/citedby.url?scp=72449190093&partnerID=8YFLogxK
U2 - 10.1111/j.1529-8019.2009.01268.x
DO - 10.1111/j.1529-8019.2009.01268.x
M3 - Article
C2 - 19891688
AN - SCOPUS:72449190093
VL - 22
JO - Dermatologic Therapy
JF - Dermatologic Therapy
SN - 1396-0296
IS - SUPPL. 1
ER -