An overview of delayed pressure urticaria with special emphasis on pathogenesis and treatment

Nicoletta Cassano, Valentina Mastrandrea, Michelangelo Vestita, Gino Antonio Vena

Research output: Contribution to journalArticlepeer-review

Abstract

Delayed pressure urticaria (DPU) is a physical urticaria characterized by the development of deep swellings at sites of pressure application on the skin. Etiopathogenesis of DPU is still unknown, although the available evidence suggests the involvement of mast cells through non-immunologic mechanisms and the role of several mediators beyond histamine, such as proinflammatory cytokines. The management of DPU is complex, also considering that prevention is very difficult and DPU frequently coexists with chronic "idiopathic" urticaria. Moreover, H1-antihistamines, which are the mainstay of treatment for common urticaria, usually provide less satisfactory results as compared with other urticarias. Therefore, numerous treatment alternatives have been proposed for severe refractory cases, such as oral or topical corticosteroids and various drugs with anti-inflammatory effects.

Original languageEnglish
JournalDermatologic Therapy
Volume22
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Nov 2009

Keywords

  • Delayed pressure urticaria
  • Pathogenesis
  • Treatment

ASJC Scopus subject areas

  • Dermatology

Fingerprint Dive into the research topics of 'An overview of delayed pressure urticaria with special emphasis on pathogenesis and treatment'. Together they form a unique fingerprint.

Cite this