An overview of the methodological approach to the in vitro study of anti-infective biomaterials

Davide Campoccia, Ilaria Cangini, Laura Selan, Marco Vercellino, Lucio Montanaro, Livia Visai, Carla Renata Arciola

Research output: Contribution to journalArticle

Abstract

Biomaterial-associated infections have an enormous impact in terms of morbidity of the patients and costs to national health systems. Perioperative antibiotics and aseptic procedures have not proved sufficient to eradicate the occurrence of this type of infections which often lead to devastating effects. Adjunctive strategies for preventing the establishment of infections are increasingly being centered on the development of new biomaterials with anti-infective properties. The creation of new anti-infective biomaterials can be obtained by alternative approaches oriented to achieve either bacteria-repellent surfaces or bioactive surfaces expressing self-sterilizing properties when not even able to treat preexisting infections in the surrounding tissues. Here, we offer a short overview of the currently available in vitro methods that can be used to investigate and assess the performance of anti-infective biomaterials, with special emphasis on those whose mechanism of action is based on bacteria-repellent surfaces.

Original languageEnglish
Pages (from-to)800-816
Number of pages17
JournalInternational Journal of Artificial Organs
Volume35
Issue number10
DOIs
Publication statusPublished - 2012

Keywords

  • Anti-infective biomaterials
  • Bacterial adhesion
  • Biofilm
  • Implant infections

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Bioengineering
  • Medicine (miscellaneous)

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