An overview on neuroprotective effects of isothiocyanates for the treatment of neurodegenerative diseases

Sabrina Giacoppo, Maria Galuppo, Sabine Montaut, Renato Iori, Patrick Rollin, Placido Bramanti, Emanuela Mazzon

Research output: Contribution to journalArticlepeer-review

Abstract

Abstract The discovery of new natural compounds with pharmacological properties is a field of interest widely growing, especially for the management of neurodegenerative diseases. As no pharmacological treatment is available to prevent the development of these disorders, dietary intake of foods or plant-based extracts with antioxidant properties might have beneficial effects on human health and improve brain functions. Isothiocyanates (ITCs), derived from the hydrolysis of the corresponding glucosinolates (GLs), mainly found in Brassica vegetables (Brassicaceae) and, to a lesser extent, in Moringaceae plants, have demonstrated to exert neuroprotective properties. Specifically, strong evidences suggest that antioxidant effects may be ascribed mainly to their peculiar ability to activate the Nrf2/ARE pathway, but alternative mechanisms of action have also been suggested. This review summarizes the current knowledge about the neuroprotective effects of ITCs in counteracting oxidative stress as well as inflammatory and apoptotic mechanisms, using in vitro and in vivo models of acute and chronic neurodegenerative disease. Therefore, ITCs could be regarded as a promising source of alternative medicine for the prevention and/or treatment of neurodegenerative diseases.

Original languageEnglish
Article number3239
Pages (from-to)12-21
Number of pages10
JournalFitoterapia
Volume106
DOIs
Publication statusPublished - Aug 12 2015

Keywords

  • Brassicaceae
  • Isothiocyanates
  • Moringaceae
  • Neurodegenerative diseases
  • Nrf2/ARE pathway
  • Oxidative stress

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Medicine(all)

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