Abstract
An atypical HIV-1 strain (CAM001) was identified in a pregnant Cameroonian woman in 1995. HMA subtyping of the env region was unsuccessful, and sequence analyses were performed. Unique sequence motifs were found at the V3 tip (GAGRALHA and GAGRAWIHA), and phylogenetic studies showed that the env C2-V5 sequence branched within group M but remained distinct from all known HIV-1 subtypes, while p17 gag branched with the subtype F sequences. Four other HIV group M viruses, undetermined by HMA, of African origin were found to cluster with CAM001 in the C2-V5 sequences. With the BLAST method, we found in databases three strains whose V3 sequences also clustered with CAM001. These unusual env sequences from eight HIV-1 strains derived from Cameroon formed a separate cluster in HIV-1 group M, which we designated k.
| Original language | English |
|---|---|
| Pages (from-to) | 1585-1589 |
| Number of pages | 5 |
| Journal | AIDS Research and Human Retroviruses |
| Volume | 15 |
| Issue number | 17 |
| DOIs | |
| Publication status | Published - Nov 20 1999 |
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ASJC Scopus subject areas
- Immunology
- Virology
Cite this
An unusual HIV type 1 env sequence embedded in a mosaic virus from cameroon : Identification of a new env clade. / Roques, P.; Menu, E.; Narwa, R.; Scarlatti, G.; Tresoldi, E.; Damond, F.; Mauclère, P.; Dormont, D.; Chaouat, G.; Simon, F.; Barré-Sinoussi, F.
In: AIDS Research and Human Retroviruses, Vol. 15, No. 17, 20.11.1999, p. 1585-1589.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - An unusual HIV type 1 env sequence embedded in a mosaic virus from cameroon
T2 - Identification of a new env clade
AU - Roques, P.
AU - Menu, E.
AU - Narwa, R.
AU - Scarlatti, G.
AU - Tresoldi, E.
AU - Damond, F.
AU - Mauclère, P.
AU - Dormont, D.
AU - Chaouat, G.
AU - Simon, F.
AU - Barré-Sinoussi, F.
PY - 1999/11/20
Y1 - 1999/11/20
N2 - An atypical HIV-1 strain (CAM001) was identified in a pregnant Cameroonian woman in 1995. HMA subtyping of the env region was unsuccessful, and sequence analyses were performed. Unique sequence motifs were found at the V3 tip (GAGRALHA and GAGRAWIHA), and phylogenetic studies showed that the env C2-V5 sequence branched within group M but remained distinct from all known HIV-1 subtypes, while p17 gag branched with the subtype F sequences. Four other HIV group M viruses, undetermined by HMA, of African origin were found to cluster with CAM001 in the C2-V5 sequences. With the BLAST method, we found in databases three strains whose V3 sequences also clustered with CAM001. These unusual env sequences from eight HIV-1 strains derived from Cameroon formed a separate cluster in HIV-1 group M, which we designated k.
AB - An atypical HIV-1 strain (CAM001) was identified in a pregnant Cameroonian woman in 1995. HMA subtyping of the env region was unsuccessful, and sequence analyses were performed. Unique sequence motifs were found at the V3 tip (GAGRALHA and GAGRAWIHA), and phylogenetic studies showed that the env C2-V5 sequence branched within group M but remained distinct from all known HIV-1 subtypes, while p17 gag branched with the subtype F sequences. Four other HIV group M viruses, undetermined by HMA, of African origin were found to cluster with CAM001 in the C2-V5 sequences. With the BLAST method, we found in databases three strains whose V3 sequences also clustered with CAM001. These unusual env sequences from eight HIV-1 strains derived from Cameroon formed a separate cluster in HIV-1 group M, which we designated k.
UR - http://www.scopus.com/inward/record.url?scp=0033589706&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033589706&partnerID=8YFLogxK
U2 - 10.1089/088922299309883
DO - 10.1089/088922299309883
M3 - Article
C2 - 10580410
AN - SCOPUS:0033589706
VL - 15
SP - 1585
EP - 1589
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
SN - 0889-2229
IS - 17
ER -