TY - JOUR
T1 - An unusual presentation of dermatofibrosarcoma protuberans with pleomorphic sarcomatous transformation
T2 - Potential pitfall and diagnostic strategy
AU - Cesinaro, Anna Maria
AU - Mataca, Ema
AU - Gambini, Claudio
AU - Kutzner, Heinz
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Dermatofibrosarcoma protuberans (DFSP) is a low grade, superficial sarcoma characterized by a proliferation of monomorphous, spindle cells arranged in a storiform pattern and infiltrating the subcutaneous tissue. The tumor is typically CD34 positive, and shows the characteristic COL1A1-PDGFB fusion gene, detectable either by florescent in situ hybridization (FISH) and polymerase chain reaction (PCR). We describe a case of DFSP with a focus of peculiar pleomorphic sarcomatous transformation. The focus constituted the entire bioptic tissue that was initially excised, raising considerable diagnostic problems for pathologist. The use of FISH as an ancillary technique allowed the right diagnosis.
AB - Dermatofibrosarcoma protuberans (DFSP) is a low grade, superficial sarcoma characterized by a proliferation of monomorphous, spindle cells arranged in a storiform pattern and infiltrating the subcutaneous tissue. The tumor is typically CD34 positive, and shows the characteristic COL1A1-PDGFB fusion gene, detectable either by florescent in situ hybridization (FISH) and polymerase chain reaction (PCR). We describe a case of DFSP with a focus of peculiar pleomorphic sarcomatous transformation. The focus constituted the entire bioptic tissue that was initially excised, raising considerable diagnostic problems for pathologist. The use of FISH as an ancillary technique allowed the right diagnosis.
KW - dermatofibrosarcoma protuberans
KW - FISH
KW - immunohistochemistry
KW - pleomorphic sarcoma
KW - transformation
UR - http://www.scopus.com/inward/record.url?scp=84971509011&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84971509011&partnerID=8YFLogxK
U2 - 10.1111/cup.12688
DO - 10.1111/cup.12688
M3 - Article
AN - SCOPUS:84971509011
VL - 43
SP - 589
EP - 593
JO - Journal of Cutaneous Pathology
JF - Journal of Cutaneous Pathology
SN - 0303-6987
IS - 7
ER -