An unusual presentation of dermatofibrosarcoma protuberans with pleomorphic sarcomatous transformation: Potential pitfall and diagnostic strategy

Anna Maria Cesinaro, Ema Mataca, Claudio Gambini, Heinz Kutzner

Research output: Contribution to journalArticlepeer-review

Abstract

Dermatofibrosarcoma protuberans (DFSP) is a low grade, superficial sarcoma characterized by a proliferation of monomorphous, spindle cells arranged in a storiform pattern and infiltrating the subcutaneous tissue. The tumor is typically CD34 positive, and shows the characteristic COL1A1-PDGFB fusion gene, detectable either by florescent in situ hybridization (FISH) and polymerase chain reaction (PCR). We describe a case of DFSP with a focus of peculiar pleomorphic sarcomatous transformation. The focus constituted the entire bioptic tissue that was initially excised, raising considerable diagnostic problems for pathologist. The use of FISH as an ancillary technique allowed the right diagnosis.

Original languageEnglish
Pages (from-to)589-593
Number of pages5
JournalJournal of Cutaneous Pathology
Volume43
Issue number7
DOIs
Publication statusPublished - Jul 1 2016

Keywords

  • dermatofibrosarcoma protuberans
  • FISH
  • immunohistochemistry
  • pleomorphic sarcoma
  • transformation

ASJC Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine
  • Histology

Fingerprint Dive into the research topics of 'An unusual presentation of dermatofibrosarcoma protuberans with pleomorphic sarcomatous transformation: Potential pitfall and diagnostic strategy'. Together they form a unique fingerprint.

Cite this