Abstract
A new case of breast tumor with features of eccrine spiradenoma is described. This neoplasm is exceedingly rare, because only two cases, arising in breast parenchima, have been previously reported. The patient was a 43- year-old woman and she experienced three local recurrences at 7, 20, and 30 months from the first excision. No distant metastases were observed. Microscopically, the tumor was circumscribed and showed a lobulated pattern. Neoplastic lobules consisted of packed, monotonous, basaloid epithelial cells with round to ovoid nuclei and scant cytoplasm. At the periphery, the lobules were delimitated by smaller cells with dark nuclei. Immunohistochemical reactivity in tumoral cells was found for both cytokeratin and epithelial membrane antigen; vimentin, muscle-specific actin, glial fibrillary acidic protein, S-100 protein, and carcinoembryonal antigen were all negative. Furthermore, the lesion showed a diffuse positivity for estrogen and progesterone receptors and a high growth fraction labelled by MIB-1 (Ki-67) antibody. These findings, in conjunction with the deep location of the tumor, suggest an origin of the neoplasm from the breast epithelium. Because of a potential local aggressive behavior, the excision of a wide rim of uninvolved breast tissue is recommended.
| Original language | English |
|---|---|
| Pages (from-to) | 665-669 |
| Number of pages | 5 |
| Journal | American Journal of Clinical Pathology |
| Volume | 106 |
| Issue number | 5 |
| Publication status | Published - Nov 1996 |
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Keywords
- Breast tumor
- Eccrine spiradenoma
- Immunohistochemistry
- MIB-1
- Steroid receptors
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
An unusual, recurring breast tumor with features of eccrine spiradenoma : A case report. / Panico, Luigi; D'Antonio, Antonio; Chiacchio, Rosistella; Delrio, Paolo; Petrella, Giuseppe; Pettinato, Guido.
In: American Journal of Clinical Pathology, Vol. 106, No. 5, 11.1996, p. 665-669.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - An unusual, recurring breast tumor with features of eccrine spiradenoma
T2 - A case report
AU - Panico, Luigi
AU - D'Antonio, Antonio
AU - Chiacchio, Rosistella
AU - Delrio, Paolo
AU - Petrella, Giuseppe
AU - Pettinato, Guido
PY - 1996/11
Y1 - 1996/11
N2 - A new case of breast tumor with features of eccrine spiradenoma is described. This neoplasm is exceedingly rare, because only two cases, arising in breast parenchima, have been previously reported. The patient was a 43- year-old woman and she experienced three local recurrences at 7, 20, and 30 months from the first excision. No distant metastases were observed. Microscopically, the tumor was circumscribed and showed a lobulated pattern. Neoplastic lobules consisted of packed, monotonous, basaloid epithelial cells with round to ovoid nuclei and scant cytoplasm. At the periphery, the lobules were delimitated by smaller cells with dark nuclei. Immunohistochemical reactivity in tumoral cells was found for both cytokeratin and epithelial membrane antigen; vimentin, muscle-specific actin, glial fibrillary acidic protein, S-100 protein, and carcinoembryonal antigen were all negative. Furthermore, the lesion showed a diffuse positivity for estrogen and progesterone receptors and a high growth fraction labelled by MIB-1 (Ki-67) antibody. These findings, in conjunction with the deep location of the tumor, suggest an origin of the neoplasm from the breast epithelium. Because of a potential local aggressive behavior, the excision of a wide rim of uninvolved breast tissue is recommended.
AB - A new case of breast tumor with features of eccrine spiradenoma is described. This neoplasm is exceedingly rare, because only two cases, arising in breast parenchima, have been previously reported. The patient was a 43- year-old woman and she experienced three local recurrences at 7, 20, and 30 months from the first excision. No distant metastases were observed. Microscopically, the tumor was circumscribed and showed a lobulated pattern. Neoplastic lobules consisted of packed, monotonous, basaloid epithelial cells with round to ovoid nuclei and scant cytoplasm. At the periphery, the lobules were delimitated by smaller cells with dark nuclei. Immunohistochemical reactivity in tumoral cells was found for both cytokeratin and epithelial membrane antigen; vimentin, muscle-specific actin, glial fibrillary acidic protein, S-100 protein, and carcinoembryonal antigen were all negative. Furthermore, the lesion showed a diffuse positivity for estrogen and progesterone receptors and a high growth fraction labelled by MIB-1 (Ki-67) antibody. These findings, in conjunction with the deep location of the tumor, suggest an origin of the neoplasm from the breast epithelium. Because of a potential local aggressive behavior, the excision of a wide rim of uninvolved breast tissue is recommended.
KW - Breast tumor
KW - Eccrine spiradenoma
KW - Immunohistochemistry
KW - MIB-1
KW - Steroid receptors
UR - http://www.scopus.com/inward/record.url?scp=0029806348&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029806348&partnerID=8YFLogxK
M3 - Article
C2 - 8929479
AN - SCOPUS:0029806348
VL - 106
SP - 665
EP - 669
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
SN - 0002-9173
IS - 5
ER -