An up-to-date vision on the aetiology and on the epidemiology of obesity and morbid obesity

Antonio Liuzzi, Anna Maria Di Blasio

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Obesity is a pathological condition characterized by an excess of body fat. Both environmental and biological factors have been considered to explain the worldwide diffusion of the obese phenotype. Most likely, the abnormal accumulation of body fat can be seen as a complex interaction between the two factors. In particular, several studies have focused on the hypothalamic mechanisms controlling food intake and energy expenditure; extensive genetic investigations have demonstrated a low but appreciable percentage of obese patients bearing a single gene mutation underlying the clinical picture. Moreover, Genome-wide association studies have shown a relevant number of loci bearing Single Nucleotide Polymorphisms that increase obesity susceptibility by interacting with environmental conditions. Obesity is now considered as a social health problem since excess of fat per se or through complex metabolic activities of adipocytes may allow the development of several chronic comorbidities such as type 2 diabetes, cardiovascular disease, liver steatosis potentially evolving to cirrhosis and sleep apnea. As a consequence, obesity must be considered a serious disease leading to poor quality of life and, potentially, severe disability.

Original languageEnglish
Title of host publicationDisabling Obesity: From Determinants to Health Care Models
PublisherSpringer-Verlag Berlin Heidelberg
Pages1-20
Number of pages20
Volume9783642359729
ISBN (Print)9783642359729, 364235971X, 9783642359712
DOIs
Publication statusPublished - Nov 1 2013

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Morbid Obesity
Epidemiology
Obesity
Adipose Tissue
Genome-Wide Association Study
Social Problems
Sleep Apnea Syndromes
Biological Factors
Fatty Liver
Adipocytes
Type 2 Diabetes Mellitus
Energy Metabolism
Single Nucleotide Polymorphism
Comorbidity
Fibrosis
Cardiovascular Diseases
Eating
Fats
Quality of Life
Phenotype

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Liuzzi, A., & Di Blasio, A. M. (2013). An up-to-date vision on the aetiology and on the epidemiology of obesity and morbid obesity. In Disabling Obesity: From Determinants to Health Care Models (Vol. 9783642359729, pp. 1-20). Springer-Verlag Berlin Heidelberg. https://doi.org/10.1007/978-3-642-35972-9_1

An up-to-date vision on the aetiology and on the epidemiology of obesity and morbid obesity. / Liuzzi, Antonio; Di Blasio, Anna Maria.

Disabling Obesity: From Determinants to Health Care Models. Vol. 9783642359729 Springer-Verlag Berlin Heidelberg, 2013. p. 1-20.

Research output: Chapter in Book/Report/Conference proceedingChapter

Liuzzi, A & Di Blasio, AM 2013, An up-to-date vision on the aetiology and on the epidemiology of obesity and morbid obesity. in Disabling Obesity: From Determinants to Health Care Models. vol. 9783642359729, Springer-Verlag Berlin Heidelberg, pp. 1-20. https://doi.org/10.1007/978-3-642-35972-9_1
Liuzzi A, Di Blasio AM. An up-to-date vision on the aetiology and on the epidemiology of obesity and morbid obesity. In Disabling Obesity: From Determinants to Health Care Models. Vol. 9783642359729. Springer-Verlag Berlin Heidelberg. 2013. p. 1-20 https://doi.org/10.1007/978-3-642-35972-9_1
Liuzzi, Antonio ; Di Blasio, Anna Maria. / An up-to-date vision on the aetiology and on the epidemiology of obesity and morbid obesity. Disabling Obesity: From Determinants to Health Care Models. Vol. 9783642359729 Springer-Verlag Berlin Heidelberg, 2013. pp. 1-20
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