An update on autoimmune retinopathy

Parthopratim Dutta Majumder, Alessandro Marchese, Francesco Pichi, Itika Garg, Aniruddha Agarwal

Research output: Contribution to journalReview articlepeer-review

Abstract

Autoimmune retinopathy (AIR) refers to a group of rare autoimmune retinal degenerative diseases presumably caused by cross-reactivity of serum autoantibodies against retinal antigens. The pathogenesis of AIR remains largely presumptive and there are a significant number of antiretinal antibodies that have been detected in association with AIR. The diagnosis of AIR is largely based on the demonstration of antiretinal antibodies in the serum along with suggestive clinical features and ancillary investigations. A high index of suspicion along with early diagnosis and treatment may play a critical role to lower the risk of irreversible immunological damage to the retinal cells in these patients. A multi-disciplinary approach for complete management and evaluation is helpful in such conditions. Various therapeutic options have been described for the treatment of AIR, though there is no consensus on standard treatment protocol.

Original languageEnglish
Pages (from-to)1829-1837
Number of pages9
JournalIndian Journal of Ophthalmology
Volume68
Issue number9
DOIs
Publication statusPublished - Sep 2020
Externally publishedYes

Keywords

  • Autoimmune retinopathy
  • cancer-associated retinopathy
  • enolase
  • melanoma-associated retinopathy
  • recoverin

ASJC Scopus subject areas

  • Ophthalmology

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