An update on the diagnosis and management of the polyneuropathy of POEMS syndrome

Research output: Contribution to journalArticle

Abstract

POEMS syndrome is a rare, chronic, disabling paraneoplastic disorder characterized by peripheral neuropathy, organomegaly, endocrinopathy, monoclonal plasma cells disorder and skin changes. Diagnosis relies on the fulfillment of a set of clinical criteria of which polyneuropathy and a monoclonal plasma cell dyscrasia are early and essential features. Treatment may be either local or systemic and is aimed at the monoclonal plasma cell disorder. Our knowledge of the pathogenesis underlying the POEMS syndrome has advanced greatly over the past years, favoring an important progression in the recognition and management of this disorder. Here, we discuss the recent literature that has advanced our knowledge of the pathogenesis and clinical management of the polyneuropathy in POEMS syndrome.

Original languageEnglish
Pages (from-to)258-267
Number of pages10
JournalJournal of Neurology
Volume266
Issue number1
DOIs
Publication statusPublished - Jan 25 2019

    Fingerprint

Keywords

  • CIDP
  • Monoclonal gammopathy
  • Nerve biopsy
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this