TY - JOUR
T1 - An update on the role of chronic rhinosinusitis with nasal polyps as a co-morbidity in severe asthma
AU - Castagnoli, Riccardo
AU - Licari, Amelia
AU - Brambilla, Ilaria
AU - Tosca, Mariangela
AU - Ciprandi, Giorgio
AU - Marseglia, Gian Luigi
N1 - Funding Information:
This paper was not funded.
Publisher Copyright:
© 2020 Informa UK Limited, trading as Taylor & Francis Group.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/12
Y1 - 2020/12
N2 - Introduction: Chronic rhinosinusitis and asthma are heterogeneous diseases with complex pathogenesis. The presence of chronic rhinosinusitis with nasal polyps has been associated with increased asthma exacerbation frequency and may represent a predictor of future exacerbations in severe asthma. Areas covered: This review provides the clinician with an overview of the prevalence and clinical impact of the chronic rhinosinusitis with nasal polyps in severe asthma and summarizes recommended therapeutic approaches, including innovative biologic therapies. To select relevant literature for inclusion in this review, we conducted a literature search using the PubMed and ClinicalTrials.gov databases, using terms ‘chronic rhinosinusitis with nasal polyps’ AND ‘asthma’ OR ‘severe asthma.’ The literature review was performed for publication years 2010–2020, restricting the articles to humans and English language publications. Expert opinion: Biological therapies have opened new perspectives in the treatment of upper and lower airway allergic diseases. Care pathways in severe asthma are almost consolidated, while they still rely on phenotypic rather than endotypic features in chronic rhinosinusitis with nasal polyps. Unveiling the correlation between clinical phenotypes and molecular endotypes will allow better stratification of patients with chronic rhinosinusitis with nasal polyps to identify candidates who benefit most from biological therapy.
AB - Introduction: Chronic rhinosinusitis and asthma are heterogeneous diseases with complex pathogenesis. The presence of chronic rhinosinusitis with nasal polyps has been associated with increased asthma exacerbation frequency and may represent a predictor of future exacerbations in severe asthma. Areas covered: This review provides the clinician with an overview of the prevalence and clinical impact of the chronic rhinosinusitis with nasal polyps in severe asthma and summarizes recommended therapeutic approaches, including innovative biologic therapies. To select relevant literature for inclusion in this review, we conducted a literature search using the PubMed and ClinicalTrials.gov databases, using terms ‘chronic rhinosinusitis with nasal polyps’ AND ‘asthma’ OR ‘severe asthma.’ The literature review was performed for publication years 2010–2020, restricting the articles to humans and English language publications. Expert opinion: Biological therapies have opened new perspectives in the treatment of upper and lower airway allergic diseases. Care pathways in severe asthma are almost consolidated, while they still rely on phenotypic rather than endotypic features in chronic rhinosinusitis with nasal polyps. Unveiling the correlation between clinical phenotypes and molecular endotypes will allow better stratification of patients with chronic rhinosinusitis with nasal polyps to identify candidates who benefit most from biological therapy.
KW - Asthma
KW - biologics
KW - chronic rhinosinusitis with nasal polyps
UR - http://www.scopus.com/inward/record.url?scp=85090084068&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85090084068&partnerID=8YFLogxK
U2 - 10.1080/17476348.2020.1812388
DO - 10.1080/17476348.2020.1812388
M3 - Review article
C2 - 32875924
AN - SCOPUS:85090084068
VL - 14
SP - 1197
EP - 1205
JO - Expert Review of Respiratory Medicine
JF - Expert Review of Respiratory Medicine
SN - 1747-6348
IS - 12
ER -