An update on the role of chronic rhinosinusitis with nasal polyps as a co-morbidity in severe asthma

Riccardo Castagnoli, Amelia Licari, Ilaria Brambilla, Mariangela Tosca, Giorgio Ciprandi, Gian Luigi Marseglia

Research output: Contribution to journalReview articlepeer-review

Abstract

Introduction: Chronic rhinosinusitis and asthma are heterogeneous diseases with complex pathogenesis. The presence of chronic rhinosinusitis with nasal polyps has been associated with increased asthma exacerbation frequency and may represent a predictor of future exacerbations in severe asthma. Areas covered: This review provides the clinician with an overview of the prevalence and clinical impact of the chronic rhinosinusitis with nasal polyps in severe asthma and summarizes recommended therapeutic approaches, including innovative biologic therapies. To select relevant literature for inclusion in this review, we conducted a literature search using the PubMed and ClinicalTrials.gov databases, using terms ‘chronic rhinosinusitis with nasal polyps’ AND ‘asthma’ OR ‘severe asthma.’ The literature review was performed for publication years 2010–2020, restricting the articles to humans and English language publications. Expert opinion: Biological therapies have opened new perspectives in the treatment of upper and lower airway allergic diseases. Care pathways in severe asthma are almost consolidated, while they still rely on phenotypic rather than endotypic features in chronic rhinosinusitis with nasal polyps. Unveiling the correlation between clinical phenotypes and molecular endotypes will allow better stratification of patients with chronic rhinosinusitis with nasal polyps to identify candidates who benefit most from biological therapy.

Original languageEnglish
Pages (from-to)1197-1205
Number of pages9
JournalExpert Review of Respiratory Medicine
Volume14
Issue number12
DOIs
Publication statusPublished - Dec 2020

Keywords

  • Asthma
  • biologics
  • chronic rhinosinusitis with nasal polyps

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine
  • Public Health, Environmental and Occupational Health

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