Anabolic deficiencies in men with systolic heart failure: Do co-morbidities and therapies really contribute significantly?

Elzbieta Kalicińska, Katarzyna Wojtas, Jacek Majda, Wolfram Doehner, Stephan Von Haehling, Waldemar Banasiak, Beata Ponikowska, Ludmila Borodulin-Nadzieja, Stefan D. Anker, Piotr Ponikowski, Ewa A. Jankowska

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Deficiencies of anabolic hormones are common in men with heart failure (HF). It remains unclear whether the deranged metabolism of these hormones is the pathophysiological element of HF itself or is the consequence of co-morbidities or/and treatment in HF. Methods: We examined 382 men with systolic HF. Serum hormones (i.e. total testosterone [TT], DHEAS, IGF-1) were assessed using immunoassays, serum free testosterone (eFT)-using the Vermeulen equation. Results: Prevalence of TT and eFT deficiencies was similar in men with HF aged

Original languageEnglish
Pages (from-to)123-131
Number of pages9
JournalAging Male
Volume16
Issue number3
DOIs
Publication statusPublished - Sep 2013

Keywords

  • Anabolic deficiency
  • Dehydroepiandrosterone sulphate
  • Heart failure
  • Insulin-like growth factor 1
  • Male ageing
  • Testosterone

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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