Squilibrio anabolico/catabolico nello scompenso cardiaco cronico

Translated title of the contribution: Anabolic/catabolic imbalance in chronic heart failure

Antonio Cittadini, Eduardo Bossone, Alberto Maria Marra, Michele Arcopinto, Emanuele Bobbio, Salvatore Longobardi, Carmine Cevara, Sara Di Michele, Luigi Saccà

Research output: Contribution to journalArticlepeer-review

Abstract

A metabolic imbalance between anabolic drive and catabolic forces is commonly observed in chronic heart failure (CHF) patients, with the latter prevailing over anabolic hormones. Moreover, anabolic deficiencies are independent markers of poor prognosis. This finding represents a solid background for the implementation of therapeutic trials based on replacement therapy. The somatotropic axis (GH/IGF-1) is the most powerful anabolic axis of the body and its decline is related with a poor outcome and a worse clinical status. Growth hormone (GH) administration may enter the therapeutic arena as adjunctive treatment in patients affected by CHF and GH/IGF-1 deficiency. The T.O.S.CA. project aims at investigating the relationship between CHF and hormonal deficiency.

Translated title of the contributionAnabolic/catabolic imbalance in chronic heart failure
Original languageItalian
Pages (from-to)53-56
Number of pages4
JournalMonaldi Archives for Chest Disease - Cardiac Series
Volume74
Issue number2
Publication statusPublished - Jun 2010

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine

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