Anaemia characterises patients with myelofibrosis harbouring Mpl W515L/K mutation

Paola Guglielmelli; Alessandro Pancrazzi; Gaetano Bergamaschi; Vittorio Rosti; Laura Villani; Elisabetta Antonioli; Alberto Bosi; Giovanni Barosi; Alessandro M. Vannucchi

doi:10.1111/j.1365-2141.2007.06565.x

Anaemia characterises patients with myelofibrosis harbouring Mpl W515L/K mutation

Paola Guglielmelli, Alessandro Pancrazzi, Gaetano Bergamaschi, Vittorio Rosti, Laura Villani, Elisabetta Antonioli, Alberto Bosi, Giovanni Barosi, Alessandro M. Vannucchi

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

The clinical and haematological phenotype of patients with myelofibrosis harbouring MPL^W515L/K mutation has not been thoroughly investigated. Of 217 myelofibrosis subjects, 18 (8·2%) had an MPL mutation, four of which (22%) co-existed with JAK2^V617F mutation. When compared with MPL wild-type patients, irrespective of JAK2^V617F status, those with MPL^W515L/K, were more frequently female, were older (61 years vs. 57 years; P = 0·02), presented with more severe anaemia (haemoglobin, 101 g/l vs. 121 g/l; P = 0·002) and were more likely to require regular transfusional support (P = 0·012). These data indicate that MPL mutation in myelofibrosis characterises patients with more severe anaemic phenotype.

Original language	English
Pages (from-to)	244-247
Number of pages	4
Journal	British Journal of Haematology
Volume	137
Issue number	3
DOIs	https://doi.org/10.1111/j.1365-2141.2007.06565.x
Publication status	Published - May 2007

Keywords

Anaemia
JAK2
MPL mutation
Myelofibrosis
Myeloproliferative disorders

ASJC Scopus subject areas

Hematology

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Anaemia characterises patients with myelofibrosis harbouring Mpl W515L/K mutation. / Guglielmelli, Paola; Pancrazzi, Alessandro; Bergamaschi, Gaetano ; Rosti, Vittorio ; Villani, Laura; Antonioli, Elisabetta; Bosi, Alberto; Barosi, Giovanni; Vannucchi, Alessandro M.

In: British Journal of Haematology, Vol. 137, No. 3, 05.2007, p. 244-247.

Research output: Contribution to journal › Article › peer-review

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abstract = "The clinical and haematological phenotype of patients with myelofibrosis harbouring MPLW515L/K mutation has not been thoroughly investigated. Of 217 myelofibrosis subjects, 18 (8·2%) had an MPL mutation, four of which (22%) co-existed with JAK2V617F mutation. When compared with MPL wild-type patients, irrespective of JAK2V617F status, those with MPLW515L/K, were more frequently female, were older (61 years vs. 57 years; P = 0·02), presented with more severe anaemia (haemoglobin, 101 g/l vs. 121 g/l; P = 0·002) and were more likely to require regular transfusional support (P = 0·012). These data indicate that MPL mutation in myelofibrosis characterises patients with more severe anaemic phenotype.",

keywords = "Anaemia, JAK2, MPL mutation, Myelofibrosis, Myeloproliferative disorders",

author = "Paola Guglielmelli and Alessandro Pancrazzi and Gaetano Bergamaschi and Vittorio Rosti and Laura Villani and Elisabetta Antonioli and Alberto Bosi and Giovanni Barosi and Vannucchi, {Alessandro M.}",

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AU - Pancrazzi, Alessandro

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AU - Rosti, Vittorio

AU - Villani, Laura

AU - Antonioli, Elisabetta

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AU - Barosi, Giovanni

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AB - The clinical and haematological phenotype of patients with myelofibrosis harbouring MPLW515L/K mutation has not been thoroughly investigated. Of 217 myelofibrosis subjects, 18 (8·2%) had an MPL mutation, four of which (22%) co-existed with JAK2V617F mutation. When compared with MPL wild-type patients, irrespective of JAK2V617F status, those with MPLW515L/K, were more frequently female, were older (61 years vs. 57 years; P = 0·02), presented with more severe anaemia (haemoglobin, 101 g/l vs. 121 g/l; P = 0·002) and were more likely to require regular transfusional support (P = 0·012). These data indicate that MPL mutation in myelofibrosis characterises patients with more severe anaemic phenotype.

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