Anaemia characterises patients with myelofibrosis harbouring Mpl W515L/K mutation

Paola Guglielmelli, Alessandro Pancrazzi, Gaetano Bergamaschi, Vittorio Rosti, Laura Villani, Elisabetta Antonioli, Alberto Bosi, Giovanni Barosi, Alessandro M. Vannucchi

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

The clinical and haematological phenotype of patients with myelofibrosis harbouring MPLW515L/K mutation has not been thoroughly investigated. Of 217 myelofibrosis subjects, 18 (8·2%) had an MPL mutation, four of which (22%) co-existed with JAK2V617F mutation. When compared with MPL wild-type patients, irrespective of JAK2V617F status, those with MPLW515L/K, were more frequently female, were older (61 years vs. 57 years; P = 0·02), presented with more severe anaemia (haemoglobin, 101 g/l vs. 121 g/l; P = 0·002) and were more likely to require regular transfusional support (P = 0·012). These data indicate that MPL mutation in myelofibrosis characterises patients with more severe anaemic phenotype.

Original languageEnglish
Pages (from-to)244-247
Number of pages4
JournalBritish Journal of Haematology
Volume137
Issue number3
DOIs
Publication statusPublished - May 2007

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Primary Myelofibrosis
Anemia
Mutation
Phenotype
Hemoglobins

Keywords

  • Anaemia
  • JAK2
  • MPL mutation
  • Myelofibrosis
  • Myeloproliferative disorders

ASJC Scopus subject areas

  • Hematology

Cite this

Anaemia characterises patients with myelofibrosis harbouring Mpl W515L/K mutation. / Guglielmelli, Paola; Pancrazzi, Alessandro; Bergamaschi, Gaetano; Rosti, Vittorio; Villani, Laura; Antonioli, Elisabetta; Bosi, Alberto; Barosi, Giovanni; Vannucchi, Alessandro M.

In: British Journal of Haematology, Vol. 137, No. 3, 05.2007, p. 244-247.

Research output: Contribution to journalArticle

Guglielmelli, P, Pancrazzi, A, Bergamaschi, G, Rosti, V, Villani, L, Antonioli, E, Bosi, A, Barosi, G & Vannucchi, AM 2007, 'Anaemia characterises patients with myelofibrosis harbouring Mpl W515L/K mutation', British Journal of Haematology, vol. 137, no. 3, pp. 244-247. https://doi.org/10.1111/j.1365-2141.2007.06565.x
Guglielmelli, Paola ; Pancrazzi, Alessandro ; Bergamaschi, Gaetano ; Rosti, Vittorio ; Villani, Laura ; Antonioli, Elisabetta ; Bosi, Alberto ; Barosi, Giovanni ; Vannucchi, Alessandro M. / Anaemia characterises patients with myelofibrosis harbouring Mpl W515L/K mutation. In: British Journal of Haematology. 2007 ; Vol. 137, No. 3. pp. 244-247.
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