Anaemia characterises patients with myelofibrosis harbouring Mpl W515L/K mutation

Paola Guglielmelli; Alessandro Pancrazzi; Gaetano Bergamaschi; Vittorio Rosti; Laura Villani; Elisabetta Antonioli; Alberto Bosi; Giovanni Barosi; Alessandro M. Vannucchi

doi:10.1111/j.1365-2141.2007.06565.x

Anaemia characterises patients with myelofibrosis harbouring Mpl W515L/K mutation

Paola Guglielmelli, Alessandro Pancrazzi, Gaetano Bergamaschi, Vittorio Rosti, Laura Villani, Elisabetta Antonioli, Alberto Bosi, Giovanni Barosi, Alessandro M. Vannucchi

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article

Abstract

The clinical and haematological phenotype of patients with myelofibrosis harbouring MPL^W515L/K mutation has not been thoroughly investigated. Of 217 myelofibrosis subjects, 18 (8·2%) had an MPL mutation, four of which (22%) co-existed with JAK2^V617F mutation. When compared with MPL wild-type patients, irrespective of JAK2^V617F status, those with MPL^W515L/K, were more frequently female, were older (61 years vs. 57 years; P = 0·02), presented with more severe anaemia (haemoglobin, 101 g/l vs. 121 g/l; P = 0·002) and were more likely to require regular transfusional support (P = 0·012). These data indicate that MPL mutation in myelofibrosis characterises patients with more severe anaemic phenotype.

Original language	English
Pages (from-to)	244-247
Number of pages	4
Journal	British Journal of Haematology
Volume	137
Issue number	3
DOIs	https://doi.org/10.1111/j.1365-2141.2007.06565.x
Publication status	Published - May 2007

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Keywords

Anaemia
JAK2
MPL mutation
Myelofibrosis
Myeloproliferative disorders

ASJC Scopus subject areas

Hematology

Cite this

Guglielmelli, P., Pancrazzi, A., Bergamaschi, G., Rosti, V., Villani, L., Antonioli, E., Bosi, A., Barosi, G., & Vannucchi, A. M. (2007). Anaemia characterises patients with myelofibrosis harbouring Mpl W515L/K mutation. British Journal of Haematology, 137(3), 244-247. https://doi.org/10.1111/j.1365-2141.2007.06565.x

Anaemia characterises patients with myelofibrosis harbouring Mpl W515L/K mutation. / Guglielmelli, Paola; Pancrazzi, Alessandro; Bergamaschi, Gaetano ; Rosti, Vittorio; Villani, Laura; Antonioli, Elisabetta; Bosi, Alberto; Barosi, Giovanni; Vannucchi, Alessandro M.

In: British Journal of Haematology, Vol. 137, No. 3, 05.2007, p. 244-247.

Research output: Contribution to journal › Article

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abstract = "The clinical and haematological phenotype of patients with myelofibrosis harbouring MPLW515L/K mutation has not been thoroughly investigated. Of 217 myelofibrosis subjects, 18 (8·2%) had an MPL mutation, four of which (22%) co-existed with JAK2V617F mutation. When compared with MPL wild-type patients, irrespective of JAK2V617F status, those with MPLW515L/K, were more frequently female, were older (61 years vs. 57 years; P = 0·02), presented with more severe anaemia (haemoglobin, 101 g/l vs. 121 g/l; P = 0·002) and were more likely to require regular transfusional support (P = 0·012). These data indicate that MPL mutation in myelofibrosis characterises patients with more severe anaemic phenotype.",

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AB - The clinical and haematological phenotype of patients with myelofibrosis harbouring MPLW515L/K mutation has not been thoroughly investigated. Of 217 myelofibrosis subjects, 18 (8·2%) had an MPL mutation, four of which (22%) co-existed with JAK2V617F mutation. When compared with MPL wild-type patients, irrespective of JAK2V617F status, those with MPLW515L/K, were more frequently female, were older (61 years vs. 57 years; P = 0·02), presented with more severe anaemia (haemoglobin, 101 g/l vs. 121 g/l; P = 0·002) and were more likely to require regular transfusional support (P = 0·012). These data indicate that MPL mutation in myelofibrosis characterises patients with more severe anaemic phenotype.

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10.1111/j.1365-2141.2007.06565.x