Anaemia characterises patients with myelofibrosis harbouring Mpl W515L/K mutation

Paola Guglielmelli, Alessandro Pancrazzi, Gaetano Bergamaschi, Vittorio Rosti, Laura Villani, Elisabetta Antonioli, Alberto Bosi, Giovanni Barosi, Alessandro M. Vannucchi

Research output: Contribution to journalArticlepeer-review

Abstract

The clinical and haematological phenotype of patients with myelofibrosis harbouring MPLW515L/K mutation has not been thoroughly investigated. Of 217 myelofibrosis subjects, 18 (8·2%) had an MPL mutation, four of which (22%) co-existed with JAK2V617F mutation. When compared with MPL wild-type patients, irrespective of JAK2V617F status, those with MPLW515L/K, were more frequently female, were older (61 years vs. 57 years; P = 0·02), presented with more severe anaemia (haemoglobin, 101 g/l vs. 121 g/l; P = 0·002) and were more likely to require regular transfusional support (P = 0·012). These data indicate that MPL mutation in myelofibrosis characterises patients with more severe anaemic phenotype.

Original languageEnglish
Pages (from-to)244-247
Number of pages4
JournalBritish Journal of Haematology
Volume137
Issue number3
DOIs
Publication statusPublished - May 2007

Keywords

  • Anaemia
  • JAK2
  • MPL mutation
  • Myelofibrosis
  • Myeloproliferative disorders

ASJC Scopus subject areas

  • Hematology

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