Abstract
The clinical and haematological phenotype of patients with myelofibrosis harbouring MPLW515L/K mutation has not been thoroughly investigated. Of 217 myelofibrosis subjects, 18 (8·2%) had an MPL mutation, four of which (22%) co-existed with JAK2V617F mutation. When compared with MPL wild-type patients, irrespective of JAK2V617F status, those with MPLW515L/K, were more frequently female, were older (61 years vs. 57 years; P = 0·02), presented with more severe anaemia (haemoglobin, 101 g/l vs. 121 g/l; P = 0·002) and were more likely to require regular transfusional support (P = 0·012). These data indicate that MPL mutation in myelofibrosis characterises patients with more severe anaemic phenotype.
| Original language | English |
|---|---|
| Pages (from-to) | 244-247 |
| Number of pages | 4 |
| Journal | British Journal of Haematology |
| Volume | 137 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - May 2007 |
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Keywords
- Anaemia
- JAK2
- MPL mutation
- Myelofibrosis
- Myeloproliferative disorders
ASJC Scopus subject areas
- Hematology
Cite this
Anaemia characterises patients with myelofibrosis harbouring Mpl W515L/K mutation. / Guglielmelli, Paola; Pancrazzi, Alessandro; Bergamaschi, Gaetano; Rosti, Vittorio; Villani, Laura; Antonioli, Elisabetta; Bosi, Alberto; Barosi, Giovanni; Vannucchi, Alessandro M.
In: British Journal of Haematology, Vol. 137, No. 3, 05.2007, p. 244-247.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Anaemia characterises patients with myelofibrosis harbouring Mpl W515L/K mutation
AU - Guglielmelli, Paola
AU - Pancrazzi, Alessandro
AU - Bergamaschi, Gaetano
AU - Rosti, Vittorio
AU - Villani, Laura
AU - Antonioli, Elisabetta
AU - Bosi, Alberto
AU - Barosi, Giovanni
AU - Vannucchi, Alessandro M.
PY - 2007/5
Y1 - 2007/5
N2 - The clinical and haematological phenotype of patients with myelofibrosis harbouring MPLW515L/K mutation has not been thoroughly investigated. Of 217 myelofibrosis subjects, 18 (8·2%) had an MPL mutation, four of which (22%) co-existed with JAK2V617F mutation. When compared with MPL wild-type patients, irrespective of JAK2V617F status, those with MPLW515L/K, were more frequently female, were older (61 years vs. 57 years; P = 0·02), presented with more severe anaemia (haemoglobin, 101 g/l vs. 121 g/l; P = 0·002) and were more likely to require regular transfusional support (P = 0·012). These data indicate that MPL mutation in myelofibrosis characterises patients with more severe anaemic phenotype.
AB - The clinical and haematological phenotype of patients with myelofibrosis harbouring MPLW515L/K mutation has not been thoroughly investigated. Of 217 myelofibrosis subjects, 18 (8·2%) had an MPL mutation, four of which (22%) co-existed with JAK2V617F mutation. When compared with MPL wild-type patients, irrespective of JAK2V617F status, those with MPLW515L/K, were more frequently female, were older (61 years vs. 57 years; P = 0·02), presented with more severe anaemia (haemoglobin, 101 g/l vs. 121 g/l; P = 0·002) and were more likely to require regular transfusional support (P = 0·012). These data indicate that MPL mutation in myelofibrosis characterises patients with more severe anaemic phenotype.
KW - Anaemia
KW - JAK2
KW - MPL mutation
KW - Myelofibrosis
KW - Myeloproliferative disorders
UR - http://www.scopus.com/inward/record.url?scp=34047211223&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34047211223&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2141.2007.06565.x
DO - 10.1111/j.1365-2141.2007.06565.x
M3 - Article
C2 - 17408465
AN - SCOPUS:34047211223
VL - 137
SP - 244
EP - 247
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 3
ER -