Anaemia is an independent predictor of poor outcome in patients with chronic heart failure

J. Szachniewicz, J. Petruk-Kowalczyk, J. Majda, A. Kaczmarek, K. Reczuch, P. R. Kalra, M. F. Piepoli, S. D. Anker, W. Banasiak, P. Ponikowski

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Background: Mild anaemia frequently occurs in patients with chronic heart failure (CHF), particularly in the advanced stages of the disease. The correction of anaemia with erythropoietin is a therapeutic possibility. The aim of this study was to assess prospectively the relationship between the prevalence of anaemia (haemoglobin level≤120 g/l) and prognosis in an unselected CHF population. Methods: All consecutive patients with a diagnosis of CHF admitted to our department between January 2000 and April 2000 were considered for the present study. Those with secondary causes of anaemia were excluded. Patients were followed up until November 2001 (>18 months in all survivors), and the end-point of the study was all-cause mortality. Results: A total of 176 patients were enrolled (mean age: 63 years, New York Heart Association (NYHA) classification I/II/III/IV: 15/81/51/29; left ventricular ejection fraction (LVEF): 42%, ischaemic aetiology in 62%). In the whole population the mean haemoglobin level was 140±15 g/l. Anaemia was found in 18 (10%) patients, and was significantly more common in women than in men (18 vs. 7%, respectively, P=0.02) and in those with most severe CHF symptoms (frequency in NYHA I/II/III/IV: 0/9/10/21%, respectively; NYHA IV vs. I-III, P=0.03), but not related to the other clinical indices. Univariate analysis revealed NYHA class III-IV (hazard ratio 3.8, 95% CI: 1.6-8.9, P=0.003), low LVEF

Original languageEnglish
Pages (from-to)303-308
Number of pages6
JournalInternational Journal of Cardiology
Issue number2-3
Publication statusPublished - Aug 2003


  • Anaemia
  • Chronic heart failure
  • Haemoglobin
  • Mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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