Anaemia management in non-dialysis chronic kidney disease (CKD) patients: A multicentre prospective study in renal clinics

Roberto Minutolo, Francesco Locatelli, Maurizio Gallieni, Renzo Bonofiglio, Giorgio Fuiano, Lamberto Oldrizzi, Giuseppe Conte, Luca De Nicola, Filippo Mangione, Pasquale Esposito, Antonio Dal Canton

Research output: Contribution to journalArticle

Abstract

Background. Knowledge on anaemia management in nondialysis chronic kidney disease (ND-CKD) patients regularly followed in renal clinics is scarce although being essential to identifying areas of therapeutic improvement. Methods. We prospectively evaluated anaemia management in two visits, performed 6 months apart, in 755 prevalent ND-CKD stage 3b-5 patients followed in 19 nephrology clinics from ≥6 months. Anaemia was defined as severe (Hb 2; male gender, diabetes and prior cardiovascular disease were 57.2, 30.1 and 30.1%, respectively. Prevalence of severe and mild anaemia was 18.0 and 44.0% at baseline and remained unchanged at Month 6 (19.3 and 43.2%). ID was prevalent at both visits (60.1 and 60.9%). Clinical inertia to ESA was similar at baseline and at Month 6 (39.6 and 34.2%, respectively, P = 0.487) and it was less frequent than clinical inertia to iron therapy (75.7 and 72.0%, respectively). Conclusions. This study shows that anaemia prevalence is unexpectedly high in the setting of tertiary nephrology care. This was due to a persistent clinical inertia in the anaemia management, remarkable for iron supplementation and less critical, but still significant, for ESA treatment.

Original languageEnglish
Pages (from-to)3035-3045
Number of pages11
JournalNephrology Dialysis Transplantation
Volume28
Issue number12
DOIs
Publication statusPublished - Dec 2013

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Keywords

  • Anaemia
  • Chronic kidney disease
  • ESA
  • Iron deficiency
  • Iron therapy

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Minutolo, R., Locatelli, F., Gallieni, M., Bonofiglio, R., Fuiano, G., Oldrizzi, L., Conte, G., De Nicola, L., Mangione, F., Esposito, P., & Dal Canton, A. (2013). Anaemia management in non-dialysis chronic kidney disease (CKD) patients: A multicentre prospective study in renal clinics. Nephrology Dialysis Transplantation, 28(12), 3035-3045. https://doi.org/10.1093/ndt/gft338