Anaerobic and aerobic relative contribution to total energy release during supramaximal effort in patients with left ventricular dysfunction

Alessandro Mezzani, Ugo Corrà, Cristina Andriani, Andrea Giordano, Roberto Colombo, Pantaleo Giannuzzi

Research output: Contribution to journalArticlepeer-review

Abstract

Energetic metabolism during effort is impaired in patients with left ventricular dysfunction (Dysf), but data have been lacking up to now on the relative anaerobic vs. aerobic contribution to total energy release during supramaximal effort. Recently, the maximal accumulated oxygen deficit (MAOD) has been shown to be measurable in Dysf patients, making it possible to evaluate the anaerobic/aerobic interaction under conditions of maximal stress of both anaerobic and aerobic metabolic pathways in this population. Nineteen Dysf patients and 17 normal patients (N) underwent one ramp cardiopulmonary, three moderate-intensity constant-power, and three supramaximal constant-power (1- to 2-min, 2- to 3-min, and 3- to 4-min duration) exercise tests. MAOD was the difference between accumulated O2 demand (accO2dem; estimated from the moderate-intensity O2 uptake/watt relationship) and uptake during supramaximal tests. Percent anaerobic (%Anaer) and aerobic (%Aer) energetic release were [(MAOD/accO2dem)·100] and 100 - %Anaer, respectively. MAOD did not vary between 1-2, 2-3, and 3-4 min supramaximal tests, whereas accO2dem increased significantly with and was linearly related to test duration in both Dysf and N. Consequently, %Anaer and %Aer decreased and increased, respectively, with increasing test duration but did not differ between Dysf and N in 1-2 min, 2-3 min, and 3-4 min tests. Our study demonstrates a similar relative anaerobic vs. aerobic contribution to total energy release during supramaximal effort in Dysf and N. This finding indicates that energetic metabolism during supramaximal exercise is exercise tolerance independent and that relative anaerobic vs. aerobic contribution in this effort domain remains the same within the physiology-or pathology-induced limits to individual peak exercise performance.

Original languageEnglish
Pages (from-to)97-102
Number of pages6
JournalJournal of Applied Physiology
Volume104
Issue number1
DOIs
Publication statusPublished - Jan 2008

Keywords

  • Energetic metabolism
  • Exercise
  • Heart failure
  • Maximal accumulated oxygen deficit
  • Peak oxygen uptake

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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