Anaerobic metabolism in hypertensive patients during exercise stress test

Giuseppe Olivo, Franceso Pestelli, Vincenzo Guarnaccia, Gian Franco Gensini, Pier Luigi Malfanti, Gian Gastone Neri Serneri

Research output: Contribution to journalArticlepeer-review


An impaired maximal vasodilating capacity has been reported in hypertensives. This study aimed to assess whether mild hypertensives depend on anaerobic metabolism more than do normal subjects during the exercise stress test. The oxygen uptake (Vo2) and carbon dioxide output (Vco2) were measured at the anaerobic threshold (AT) and at peak exercise (Vo2p and Vco2p) during the cardiopulmonary exercise test by breath-by-breath expiratory gas analysis in 21 mild hypertensives and 19 age-matched normotensives. AT was reached earlier in hypertensives than in normotensives, but with similar Vo2 uptake, Vco2 output, and Vco2/Vo2 ratio. At peak exercise, however, hypertensives showed lower Vo2p than controls (29 ± 5 υ 33 ± 5 mL Vo2/kg/min, (P 2p (36 ± 6 υ 39 ± 6 mL Vco2/kg/min, P =.19). As a result, the slope of carbon dioxide output increase versus oxygen uptake after anaerobic threshold was steeper in hypertensives than in controls (P 2 in hypertensives as compared with controls seems to reflect a greater involvement of the anaerobic metabolism to supplement energy output. Am J Hypertens 1994:7:469-473.

Original languageEnglish
Pages (from-to)469-473
Number of pages5
JournalAmerican Journal of Hypertension
Issue number5
Publication statusPublished - 1994


  • Exercise stress test
  • Hypertension
  • Oxygen consumption
  • Pulmonary ventilation

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine


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