Anaesthesia for ultrasound guided oocyte retrieval: Midazolam/remifentanil versus propofol/fentanyl regimens

A. Casati, G. Valentini, A. Zangrillo, R. Senatore, A. Mello, B. Airaghi, G. Torri

Research output: Contribution to journalArticlepeer-review


To evaluate the quality of intra-operative anaesthesia and recovery characteristics of two different anaesthesia regimens, 60 healthy women undergoing ultrasound guided oocyte retrieval for in vitro fertilization procedures were randomly allocated to receive either a propofol/fentanyl or a midazolam/remifentanil based anaesthesia. The surgical procedure was successful in all patients and no severe side effects were reported by any patient. Four patients in the midazolam/remifentanil group (13%) would not accept the same anaesthetic procedure for further in vitro fertilization treatment due to intra-operative awareness, while all propofol/fentanyl patients were prepared to accept the same procedure again (P <0.05). Patients in the propofol/fentanyl group required manual ventilation more frequently through a facemask than those patients treated with the midazolam/remifentanil combination (50% and 30%, respectively; P <0.05). The time to achieve an Aldrete's score of 10 was shorter in the midazolam/remifentanil patients (2 ± 2 min) than in those who received propofol/fentanyl (4 ± 2 min) (P <0.001), but no differences were observed in the time required to be 'fit to discharge' from the post-anaesthesia care unit. We conclude that the use of a midazolam/remifentanil regimen is as effective and safe as a fentanyl/propofol regimen in patients undergoing transvaginal oocyte retrieval for in vitro fertilization procedures.

Original languageEnglish
Pages (from-to)773-778
Number of pages6
JournalEuropean Journal of Anaesthesiology
Issue number11
Publication statusPublished - 1999


  • Ambulatory anaesthesia
  • Anaesthetic
  • Fent anyl
  • In vitro fertilization
  • Intravenous
  • Midazolam
  • Opioids
  • Propofol
  • Remifentanil

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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