Anal human papillomavirus infection: prevalence, diagnosis and treatment of related lesions

Research output: Contribution to journalReview articlepeer-review


Human papillomavirus (HPV) infection is mostly asymptomatic, but may also have many diverse clinical signs encompassing benign ano-genital lesions, and carcinomas. Recently, interest has also particularly focused on anal cancer since, over the last decades, its incidence has been greatly increasing in developed countries, both in women and men and is drastically higher in specific risk groups, such as men who have sex with men (MSM) and HIV-1 infected individuals. Approximately 88% of anal cancer cases worldwide are associated with HPV infection. This review summarizes our current understanding of anal HPV infection, discussing its epidemiology and risk factors in various populations, and the state of the art in the detection of anal HPV infection and its related lesions through both cytology and histology. Finally, we discuss the clinical management and therapy for these lesions.

Original languageEnglish
Pages (from-to)465-477
Number of pages13
JournalExpert Review of Anti-Infective Therapy
Issue number5
Publication statusPublished - May 3 2016


  • anal cancer
  • anal infection
  • cytology
  • high resolution anoscopy (HRA)
  • histology
  • HPV
  • imiquimod
  • MSM
  • podophyllotoxin
  • sinecatechins
  • topical 5-fluorouracil
  • treatment

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology


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